AI Article Synopsis
- The controlled human infection model (CHIM) for enterotoxigenic Escherichia coli (ETEC) has helped identify ETEC as a major cause of acute watery diarrhea, improving understanding of the disease and immune responses.
- Over a dozen ETEC strains have been tested, mimicking symptoms of natural infections, which is essential for evaluating vaccines and treatments.
- Recent advancements in the CHIM technology, combined with omics-based approaches, are expected to enhance insights into host-pathogen interactions and support the creation of prevention strategies.
Article Abstract
The controlled human infection model (CHIM) for enterotoxigenic Escherichia coli (ETEC) has been instrumental in defining ETEC as a causative agent of acute watery diarrhea, providing insights into disease pathogenesis and resistance to illness, and enabling preliminary efficacy evaluations for numerous products including vaccines, immunoprophylactics, and drugs. Over a dozen strains have been evaluated to date, with a spectrum of clinical signs and symptoms that appear to replicate the clinical illness seen with naturally occurring ETEC. Recent advancements in the ETEC CHIM have enhanced the characterization of clinical, immunological, and microbiological outcomes. It is anticipated that omics-based technologies applied to ETEC CHIMs will continue to broaden our understanding of host-pathogen interactions and facilitate the development of primary and secondary prevention strategies.
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| http://dx.doi.org/10.1007/82_2021_242 | DOI Listing |
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