Nontuberculous mycobacteria (NTM) are widespread in the environment and can cause various diseases in humans, especially immunocompromised patients. Treatment of diseases caused by NTM is a complicated issue, mainly due to the resistance of the pathogen to most antimicrobial agents. Bedaquiline (Bdq) is now widely used for the treatment of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB). The main goal of our study was to evaluate the activity of Bdq against complex (MAC), the most common species among NTM. A total of 166 MAC cultures (124 and 42 ) were studied. The minimum inhibitory concentrations (MICs) of Bdq for and were obtained by twofold serial dilutions in the Middlebrook 7H9 medium. MIC ranges were determined and the MIC, MIC and ECOFF values were obtained. The MICs in respect of ranged from 0.003 to 1.0 µg ml; those for ranged from 0.003 to 0.5 µg ml. The Bdq MIC and MIC values were found to be 0.015 and 0.12 µg ml respectively, for and 0.007 and 0.06 µg ml, respectively, for . The tentative ECOFF values for and were 0.12 and 0.06 µg ml, respectively. The main bedaquiline susceptibility parameters for MAC strains isolated in the Moscow region were determined.
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