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The topography of nullomer-emerging mutations and their relevance to human disease.
Comput Struct Biotechnol J
December 2024
Institute for Personalized Medicine, Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, PA, USA.
Nullomers are short DNA sequences (11-18 base pairs) that are absent from a genome; however, they can emerge due to mutations. Here, we characterize all possible putative human nullomer-emerging single base pair mutations, population variants and disease-causing mutations. We find that the primary determinants of nullomer emergence in the human genome are the presence of CpG dinucleotides and methylated cytosines.
View Article and Find Full Text PDFSeasonal Land Use and Land Cover Mapping in South American Agricultural Watersheds Using Multisource Remote Sensing: The Case of Cuenca Laguna Merín, Uruguay.
Sensors (Basel)
January 2025
Departamento de Geografía, Facultad de Ciencias, Universidad de la República, Montevideo 4225, Uruguay.
Recent advancements in Earth Observation sensors, improved accessibility to imagery and the development of corresponding processing tools have significantly empowered researchers to extract insights from Multisource Remote Sensing. This study aims to use these technologies for mapping summer and winter Land Use/Land Cover features in Cuenca de la Laguna Merín, Uruguay, while comparing the performance of Random Forests, Support Vector Machines, and Gradient-Boosting Tree classifiers. The materials include Sentinel-2, Sentinel-1 and Shuttle Radar Topography Mission imagery, Google Earth Engine, training and validation datasets and quoted classifiers.
View Article and Find Full Text PDFTricuspid Anteroposterior Patch Repair: Optimization of Patch Geometry in an Ex Vivo Model.
Ann Thorac Surg Short Rep
June 2024
Division of Cardiac Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Background: Tricuspid anteroposterior patch (TRAPP) repair aims to address shortcomings of traditional annuloplasty in functional tricuspid regurgitation by selectively enlarging and translocating the anterior and posterior leaflets, but optimal patch width has not been identified.
Methods: An ex vivo model of the tricuspid valve was established in fresh porcine hearts by pneumatic pressurization of the ventricles. TRAPP repair was performed with patches of varying width (group 1, 1.
Designing highly tunable nanostructured peptide hydrogels using differential thermal histories to achieve variable cellular responses.
Nanoscale
January 2025
Institute of Nano Science and Technology, Mohali, Sector-81, Knowledge City, Sahibzada Ajit Singh Nagar, Punjab 140306, India.
In this study, we demonstrate a unique and promising approach to access peptide-based diverse nanostructures in a single gelator regime that is capable of exhibiting different surface topographies and variable physical properties, which, in turn, can effectively mimic the extracellular matrix (ECM) and regulate variable cellular responses. These diverse nanostructures represent different energy states in the free energy landscape, which have been created through different self-assembling pathways by providing variable energy inputs by simply altering the gelation induction temperature from 40 °C to 90 °C. The highly entangled network structure with long fibers was created by higher energy inputs, , inducing the gelation at a higher temperature in the 70-90 °C range, whereas the less entangled nanoscale network with short fibers was obtained at a lower gelation induction temperature of 40-60 °C.
View Article and Find Full Text PDFThe influence of post-glacial migration and hybridization on the gene pool of marginal Quercus pubescens populations in Central Europe.
Ann Bot
December 2024
Department of Forest and Soil Sciences, Institute of Silviculture, BOKU University; Peter-Jordan-Str. 82, AT-1190 Vienna, Austria.
Background And Aims: In Central Europe, the drought-tolerant downy oak (Quercus pubescens) is at the northern edge of its natural distribution range, often growing in small and spatially isolated populations. Here, we elucidate how the population genetic structure of Central European Q. pubescens was shaped by geographic barriers, genetic drift and introgression with the closely related sessile oak (Q.
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