Opioid-related respiratory depression is a serious clinical problem as it can cause multiple deaths and anoxic brain injury. Genetic variations influence the safety and clinical efficacy of fentanyl. Pharmacogenetic studies help in identifying single-nucleotide polymorphisms (SNPs) associated with fentanyl causing respiratory depression and aid clinician in personalized pain medicine. This narrative review gives an insight of the common SNPs associated with fentanyl.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8462425 | PMC |
| http://dx.doi.org/10.4103/aer.aer_94_21 | DOI Listing |
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