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Rapamycin facilitates healing of the tendon-bone interface in an aging rat model of chronic rotator cuff injury.
J Shoulder Elbow Surg
September 2024
Department of Orthopedics, Orthopedic Hospital of Guangdong Province, Academy of Orthopedics·Guangdong Province, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China; Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China. Electronic address:
Background: Tendon-bone interface (TBI) healing in chronic rotator cuff injury (CRCI) in older individuals is a common clinical challenge due to cellular senescence, as well as decreased tissue repair and regeneration. Many studies have demonstrated the antiaging, improved tissue repair, and bone regeneration properties of rapamycin (RPM) in multiple age-related diseases. This study aimed to explore the effects of RPM on TBI healing after CRCI in an aging rat model.
View Article and Find Full Text PDFIn Vitro Handling Characteristics of a Particulate Bone Substitute for Ridge Preservation Procedures.
Materials (Basel)
January 2024
Department of Prosthodontics, Saarland University, 66421 Homburg, Saar, Germany.
While particulate bone substitute materials are applied in a variety of augmentation procedures, standardized defects are being used for preclinical testing. This in vitro study evaluated the density and homogeneity of a particulate bone substitute in ridge preservation procedures. Premolars and molars were extracted in ten semimandibles of minipig cadavers.
View Article and Find Full Text PDFThis evaluation correlates maxillary sinus 3D morphology with bone regeneration. In 39 patients with crestal bone ≤ 2 mm, mineralized human bone allografts were used to augment the sinus floor through the crestal window sinus elevation approach. CBCT was used to measure the buccopalatal diameter (BPD), mesiodistal diameter (MDD), and hemi-ellipsoidal volume (Vh) in all sinuses.
View Article and Find Full Text PDFObservations of bony ongrowth and clinical fixation in two retrieved disc replacements.
J Biomed Mater Res B Appl Biomater
September 2023
The J. Vernon Luck, Sr., M.D. Orthopaedic Research Center, The Luskin Orthopaedic Institute for Children in Alliance with UCLA, Los Angeles, CA, United States.
Total disc replacements utilize textured coatings to maximize bony ongrowth. However, the contribution of direct bony attachment to overall fixation for total disc replacements has not been reported. The goal of the present study was to document the extent of bony attachment to the surfaces of two clinically functional total disc replacements that were securely fixed at the time of revision.
View Article and Find Full Text PDFTopographic Assessment of Calcified Material After Sinus Floor Augmentation.
Int J Oral Maxillofac Implants
December 2021
Purpose: This study aimed to topographically examine the healing of mineralized human bone allograft in sinus augmentation.
Materials And Methods: Thirty-two patients with crestal bone height ≤ 2 mm who required sinus augmentation were recruited for the study. A mixture of 80/20 cortical/cancellous mineralized human bone allografts were used to augment the sinus floor using a crestal window approach.
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