Safety evaluation of signalized intersections is often conducted by developing statistical and data-driven methods based on data aggregated at certain temporal and spatial levels (e.g., yearly, hourly, or per signal cycle; intersection or approach leg). However, such aggregations are subject to a major simplification that masks the underlying spatio-temporal safety risk patterns within the data aggregation levels. Consequently, high-resolution analysis such as safety risk within signal cycles and at traffic movement level cannot be performed. This study contributes to the literature by proposing a new functional data analysis (FDA) approach for a novel characterization of safety risk patterns of signalized intersections. Functional data smoothing methods that can mitigate overfitting and account for the nonnegative characteristics of safety risk are proposed to model the time series of safety risk within signal cycles at the traffic movement level. Functional analysis of variance method (FANOVA) that can compare the group level differences of functional curves is used to test differences of safety risk functions among different traffic movements. A typical signalized intersection with representative signal types and channelizations is selected as the study location and approximately 1-hour traffic video data recorded by an unmanned aerial vehicle are used to extract traffic conflicts. New movement-level safety risk patterns are characterized based on the safety risk functions that can reveal the temporal distribution of risk within signal cycles. Most of the tested traffic movements have significantly distinct functional risk patterns according to the FANOVA results while risk patterns for most of the traffic movements cannot be differentiated based on the data aggregated at the cycle and approach levels. The proposed functional approach has the potential to be used for facilitating proactive safety management, calibrating microsimulation models for safety evaluation, and optimizing signal timing while considering traffic safety at more disaggregated levels.
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http://dx.doi.org/10.1016/j.aap.2021.106446 | DOI Listing |
JAMA Oncol
January 2025
Children's Wisconsin, Milwaukee.
Importance: Retrieval strategies for children, adolescents, and young adults with relapsed classic Hodgkin lymphoma (cHL) aim to maintain efficacy while minimizing long-term toxic effects. Children, adolescents, and young adults with low-risk, relapsed cHL may benefit from replacing high-dose chemotherapy and autologous stem cell transplant with less intensive involved-site radiotherapy (ISRT).
Objective: To evaluate a risk-stratified, response-adapted, transplant-free approach for treatment of children, adolescents, and young adults with low-risk relapsed cHL with nivolumab plus brentuximab vedotin (BV) followed by BV plus bendamustine for patients with suboptimal response and ISRT (30.
Invest Ophthalmol Vis Sci
January 2025
Laboratory of Anatomy of Domestic Animals, National Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Haidian, Beijing, China.
Purpose: Because chickens have excellent light perception properties, this study focused on investigating whether monochromatic light can cause photodamage in chicken retinal ganglion cells (RGCs).
Methods: Post-hatching day chickens were exposed to four different light-emitting diode light environments for five weeks, respectively, monochromatic blue light (480 nm), green light (560 nm), red light (660 nm), or white light (6000 K). The mechanisms through which monochromatic light influences the structure of the chicken retina were analyzed by detecting the morphological structure of the retina, gene and protein expression levels, and the ultrastructure of the optic nerve.
Invest Ophthalmol Vis Sci
January 2025
Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Purpose: This study aimed to identify a novel recombinant adeno-associated virus (rAAV) capsid variant that can widely transfect the deep retina through intravitreal injection and to assess their effectiveness and safety in gene delivery.
Methods: By adopting the sequences of various cell-penetrating peptides and inserting them into the capsid modification region of AAV2, we generated several novel variants. The green fluorescent protein (GFP)-carrying variants were screened following intravitreal injection.
Health Psychol
January 2025
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles.
Objective: Although sexual minority men experience substantial discrimination, in addition to increased risk for several serious mental and somatic health problems, the biological mechanisms underlying these effects are unclear. To address this issue, we examined how experiences of social safety (i.e.
View Article and Find Full Text PDFBiol Trace Elem Res
January 2025
Department of Fisheries, Faculty of Marine Sciences and Fisheries, University of Chittagong, Chittagong, 4331, Bangladesh.
The Southeastern part of the Bay of Bengal is increasingly threatened by heavy metal pollution, posing significant risks to both aquatic life and human health. In this context, the contamination levels of six heavy metals-Cadmium (Cd), Lead (Pb), Zinc (Zn), Copper (Cu), Manganese (Mn), and Iron (Fe)-were assessed in the soft tissues of Green mussels (Perna viridis) from five key sites: Matamuhuri, Moheshkhali, Bakhkhali, Naf, and St. Martin.
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