AI Article Synopsis
- - The study investigates how MRI measures of brain atrophy relate to cognitive outcomes in early-onset Alzheimer’s disease (EOAD) patients, focusing on those under 65 with confirmed diagnoses using biomarkers.
- - Researchers assessed 48 EOAD patients and 42 healthy controls using neuropsychological evaluations, MRI scans, and lumbar punctures, then tracked cognitive changes over two years.
- - Key findings reveal that baseline cortical thickness and ventricular volume in EOAD patients were significant predictors of cognitive abilities like global cognition, language, and executive functioning, while hippocampal volume showed no significant impact.
Article Abstract
Background: MRI atrophy predicts cognitive status in AD. However, this relationship has not been investigated in early-onset AD (EOAD, < 65 years) patients with a biomarker-based diagnosis.
Methods: Forty eight EOAD (MMSE ≥ 15; A + T + N +) and forty two age-matched healthy controls (HC; A - T - N -) from a prospective cohort underwent full neuropsychological assessment, 3T-MRI scan and lumbar puncture at baseline. Participants repeated the cognitive assessment annually. We used linear mixed models to investigate whether baseline cortical thickness (CTh) or subcortical volume predicts two-year cognitive outcomes in the EOAD group.
Results: In EOAD, hemispheric CTh and ventricular volume at baseline were associated with global cognition, language and attentional/executive functioning 2 years later (p < 0.0028). Regional CTh was related to most cognitive outcomes (p < 0.0028), except verbal/visual memory subtests. Amygdalar volume was associated with letter fluency test (p < 0.0028). Hippocampal volume did not show significant associations.
Conclusion: Baseline hemispheric/regional CTh, ventricular and amygdalar volume, but not the hippocampus, predict two-year cognitive outcomes in EOAD.
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| http://dx.doi.org/10.1007/s00415-021-10851-9 | DOI Listing |
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