AI Article Synopsis
- Irritant contact dermatitis (ICD) is a significant occupational disease, and this review aimed to assess how occupational irritants relate to ICD and its prognosis.
- The findings indicate strong associations between ICD and factors like wet work and non-alcoholic disinfectants, with moderate evidence linking it to metalworking fluids and limited evidence for mechanical exposure and glove use.
- Despite the poor prognosis for complete healing of ICD, improving conditions by reducing exposure can enhance recovery, although study biases may affect results.
Article Abstract
Purpose: Irritant contact dermatitis (ICD) is a major cause of occupational disease. The aim was to review the relation between exposure to occupational irritants and ICD and the prognosis of ICD.
Methods: Through a systematic search, 1516 titles were identified, and 48 studies were included in the systematic review.
Results: We found that the evidence for an association between ICD and occupational irritants was strong for wet work, moderate for detergents and non-alcoholic disinfectants, and strong for a combination. The highest quality studies provided limited evidence for an association with use of occlusive gloves without other exposures and moderate evidence with simultaneous exposure to other wet work irritants. The evidence for an association between minor ICD and exposure to metalworking fluids was moderate. Regarding mechanical exposures, the literature was scarce and the evidence limited. We found that the prognosis for complete healing of ICD is poor, but improves after decrease of exposure through change of occupation or work tasks. There was no substantial evidence for an influence of gender, age, or household exposures. Inclusion of atopic dermatitis in the analysis did not alter the risk of ICD. Studies were at risk of bias, mainly due to selection and misclassification of exposure and outcome. This may have attenuated the results.
Conclusion: This review reports strong evidence for an association between ICD and a combination of exposure to wet work and non-alcoholic disinfectants, moderate for metalworking fluids, limited for mechanical and glove exposure, and a strong evidence for a poor prognosis of ICD.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8755674 | PMC |
| http://dx.doi.org/10.1007/s00420-021-01781-0 | DOI Listing |
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