A new CEST-MRI contrast agent, 2-HYNIC, capable of sensing aromatic aldehydes is reported. Pyridoxal 5'-phosphate, a key Vitamin B metabolite necessary for >140 biotransformations was mapped by CEST-MRI and in lung cancer. 2-HYNIC provided access to this key biomarker associated with a variety of human diseases.
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| http://dx.doi.org/10.1039/d1cc03704h | DOI Listing |
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