AI Article Synopsis
- Prolonging protein expression from mRNA is difficult in mRNA nanomedicine development.
- Complexing mRNA with helix foldamer oligopeptides made of arginine and α-aminoisobutyric acids enhances intracellular stability.
- This combination allows for efficient protein translation that lasts up to three days.
Article Abstract
Prolonging the duration of protein expression from mRNA is a major challenge in the development of mRNA nanomedicines. mRNA complexed with helix foldamer oligopeptides consisting of arginine and α-aminoisobutyric acids showed higher intracellular stability than that complexed with oligoarginines, thereby maintaining efficient protein translation for three days.
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| http://dx.doi.org/10.1039/d1nr03600a | DOI Listing |
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