Synchrotron-based techniques have been key tools in the discovery, understanding, and development of battery materials. In this review, some of the most suitable X-ray spectroscopy related techniques employed for addressing diverse scientific cases connected to battery science are highlighted. Furthermore, current shortcomings, intrinsic limitations, and ongoing challenges of individual techniques are pointed out, providing an outlook of future trends that are relevant to the battery research community. In particular, the ongoing development of next generation synchrotrons, machine learning algorithms for data analysis and combined theoretical/experimental approaches will enhance the already powerful assets of these advanced spectroscopic methods.
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http://dx.doi.org/10.1039/d1cp03263a | DOI Listing |
Alzheimers Dement
December 2024
Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Centro de Neurociencias, Panamá, Panamá, Panama.
Background: By 2025, an estimated three-quarters of the global population aged 60 and older will live in Latin American and Caribbean countries (LAC), leading to a rise in age-related conditions. The main goal of the Panama Aging Research Initiative - Health Disparities (PARI-HD) research program is to create a platform for multidisciplinary clinical studies that focus on mental health and its diseases such as age-related cognitive decline. This platform would generate a large amount of clinical, neuropsychological, lifestyle, genetic and biomarker data following standardized research protocols.
View Article and Find Full Text PDFWhite matter hyperintensities (WMH) are areas of increased lucency visualized on T2-weighted magnetic resonance imaging (MRI), including fluid attenuated inversion recovery (FLAIR) sequences. Over the past 15 years we have been examining WMH in studies of cognitive aging among clinical, community-based, and populations at genetic risk to understand the role of vascular brain injury in Alzheimer's disease (AD) onset, symptom progression, and pathogenesis. Our findings suggest that regional WMH, particularly when distributed in posterior areas, increase risk for clinical AD and contribute to the clinical course of the disease, even among genetic population with relatively low rates of vascular risk factor, like adults with Down syndrome and with autosomal dominant genetic mutations for AD.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Department of Molecular Imaging & Therapy, Austin Health, Heidelberg, VIC, Australia.
Background: Rise in plasma phospho-tau (pTau) is hypothesized to reflect a physiological response to brain Aβ plaques, preceding the formation of neurofibrillary tangles (NFT). An alternate explanation is poor sensitivity of tau PET for detection of early NFT formation. The tau tracer MK6240 has very low background "off-target" binding and may better detect early tau aggregation.
View Article and Find Full Text PDFBackground: Recent advances in Alzheimer's Disease (AD) disease modifying therapies (DMTs) emphasize the need of an early, timely and accurate diagnosis to initiate treatment and improve patient outcomes. Clinicians must confirm amyloid pathology through cerebrospinal fluid (CSF) testing or amyloid positron emission tomography (PET) scan to qualify patients. As a result, the demand for confirmatory CSF or imaging biomarker testing is predicted to rise significantly.
View Article and Find Full Text PDFBackground: The global population of adults over the age of 65 is expected to surpass 2 billion by 2050. Alongside this rise in the aging population, the incidence of age-related cognitive decline and dementia will continue to grow. Importantly, women are at an elevated risk of cognitive decline compared to men.
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