Telavancin, a lipoglycopeptide antibiotic, is traditionally dosed at 10 mg/kg based on total body weight but is associated with toxicities that limit its use. This study supports the use of a capped dosing regimen of 750 mg in obese patients, which is associated with equal efficacy and fewer adverse effects compared to traditional dosing.
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http://dx.doi.org/10.1128/AAC.01603-21 | DOI Listing |
Am J Emerg Med
December 2024
Department of Pharmacy, Children's Hospital Colorado, Aurora, CO, United States of America.
Background: The use of ketorolac for analgesia in the emergency department is a common practice for pediatric patients. There is a lack of guidance on optimal dosing to limit the risk of side effects especially in pediatric patients. The standard dosing is weight based with a cap at 30 mg, a dose which is higher than the typical max used for adult patients.
View Article and Find Full Text PDFFungal Biol
December 2024
ICAR-CAZRI, 17E/361A, Chopasni Housing Board, Jodhpur, 342008, India. Electronic address:
A32 kDa protein from fungi can be used to produce nanoparticles which might be use as nanofertilisers needed by plants. There are large numbers of fungi which can be used for the efficient synthesis of nanofertiliser particles. Generally, the formation of nanoparticles by fungi involves metal capture, enzymatic reduction and capping on their surface.
View Article and Find Full Text PDFSci Rep
December 2024
Department of Life Sciences, Yeungnam University, Gyeongsan, 38541, Republic of Korea.
Green nanomaterials are increasingly used to improve plant growth and phytochemical traits. This study employed Eucalyptus globulus leaf extract, a medicinal plant, as a bio-reductant and capping agent to synthesize copper oxide nanoparticles (CuO-NPs), which were applied as seed primers for Lactuca sativa (lettuce), an annual species prized for its short germination time and rich bioactive compounds. Characterization of CuO-NPs using FTIR, XRD, SEM, and EDX confirmed their purity, crystalline structure, and an average particle size of 74.
View Article and Find Full Text PDFChemosphere
October 2024
Department of Ecology, Environment and Plant Sciences (DEEP), Stockholm University, Svante Arrhenius väg 20A, 106 91, Stockholm, Sweden. Electronic address:
Nat Biotechnol
September 2024
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.
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