AI Article Synopsis
- Researchers designed and synthesized a new series of chemical compounds based on benzimidazole and benzoxazole derivatives.
- A cytotoxicity study of 26 selected compounds conducted by the National Cancer Institute revealed two compounds, 10e and 11s, with significant anti-cancer effects against human tumor cell lines.
- Flow cytometry analysis indicated that compound 10e caused cell cycle arrest in the G2/M phase and increased apoptosis in K-562 leukemia cells in a dose-dependent manner.
Article Abstract
In this contribution, we report the design, synthesis and cytotoxicity studies of a series of N-[3-(benzimidazol-2-yl-amino)phenyl]amine and N-[3-(benzoxazol-2-ylamino)phenyl]amine derivatives. In vitro cytotoxicity assay of 26 selected compounds was carried out at National Cancer Institute (NCI), USA. Out of them, compounds 10e (NSC D-762842/1) and 11s (NSC D-764942/1) have shown remarkable cytotoxicity with GI values ranging between "0.589-14.3 µM" and "0.276-12.3 µM," respectively, in the representative nine subpanels of human tumor cell lines. Further, flow cytometry analysis demonstrated that compound 10e exerted cell cycle arrest at G2/M phase and showed dose-dependent enhancement in apoptosis in K-562 leukemia cancer cells.
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| http://dx.doi.org/10.1007/s11030-021-10333-0 | DOI Listing |
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