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| http://dx.doi.org/10.1016/j.ekir.2021.10.004 | DOI Listing |
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Endocarditis Mimicking ANCA-Associated Vasculitis.
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Internal Medicine, Ascension Saint John Hospital, Detroit, Michigan, USA.
Bacterial endocarditis presents as inflammation of the endocardium and valves of the 4 layers of the heart. The presentation and sequelae of bacterial endocarditis may vary and in certain circumstances may mimic rheumatologic disease. Antinuclear cytoplasmic antibody (ANCA)-positive bacterial endocarditis constitutes a special subgroup of bacterial endocarditis.
View Article and Find Full Text PDFCell-to-cell adhesion via CD54 (intercellular adhesion molecule-1)-associated cell proliferation in diffuse large B-cell lymphoma cases.
J Clin Exp Hematop
December 2024
Department of Diagnostic Pathology, School of Medicine, Fukushima Medical University, Fukushima city, Japan.
Cluster of Differentiation 54 (CD54), also known as intracellular adhesion molecule-1 (ICAM-1), is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. Although CD54 has been shown to be involved in cell-to-cell adhesion and proliferation of B-cell lymphoma cell lines, the clinical significance of its expression has not yet been elucidated. We analyzed Ki-67 indices, the expression status of CD54 and its receptor (CD11a), and the intercellular distance of tumor cells in 40 diffuse large B-cell lymphoma (DLBCL) cases with vascular invasion to analyze the association of cell adhesion and proliferation status.
View Article and Find Full Text PDFPediatric double-seropositive anti-glomerular basement membrane antibody disease: A case report and literature review.
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Department of Pediatrics, Cheikh Khalifa International University Hospital, Faculty of Medicine, Mohammed VI University of Health Sciences (UM6SS), Casablanca, Morocco.
Introduction: Glomerular basement membrane (GBM) disease is a severe and exceedingly rare disorder characterized by the presence of circulating antibodies targeting the non-collagen NC1 domain of the α3 chain of collagen type IV in glomerular and alveolar basement membranes. It typically presents as rapidly progressive glomerulonephritis (RPGN), often accompanied by pulmonary hemorrhage. The occurrence of double-seropositivity for anti-GBM antibody and anti-neutrophil cytoplasmic antibody (ANCA), primarily with myeloperoxidase specificity (MPO-ANCA), is particularly uncommon in pediatric cases.
View Article and Find Full Text PDFPrognostic impact of EGFR expression and immunohistochemistry-based "molecular classification" in bladder cancer.
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Department of Pathology, Rize Recep Tayyip Erdogan University Faculty of Medicine, Rize, Turkey.
Recent genomic studies emphasize the necessity of molecular classification to reflect diverse clinical and pathological characteristics of bladder cancer. Immunohistochemically bladder cancer can be classified into molecular subtypes, including basal, luminal, and p53-like subtypes. Epidermal growth factor receptor (EGFR) is frequently expressed in basal-type bladder cancers and is associated with poor prognosis.
View Article and Find Full Text PDFHuman Papillomaviruses 16 and 18 E6 Oncoprotein Detection Test in Primary Oropharyngeal Carcinomas and Metastatic Lymph Nodes: A Cross-Sectional Study.
Head Neck Pathol
October 2024
Department of Medical, Surgical and Health Sciences, Section of Otolaryngology, University of Trieste, Trieste, Italy.
Purpose: Accuracy in the diagnosis of HPV-associated oropharyngeal carcinoma (OPSCC) of a rapid, low-cost lateral flow immunochromatographic assay for detecting E6 oncoprotein of HPV-16 and HPV-18 was previously evaluated in a small pilot study. This cross-sectional study aimed to assess on a large case series the sensitivity and specificity of E6 oncoprotein as a diagnostic marker for HPV-associated carcinogenesis in OPSCC.
Methods: 137 consecutive patients with histologically confirmed OPSCC were enrolled in two hospitals in Northeast Italy.
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