Genetic Mutations in Were Associated With the Chronicity of Hepatitis C Among Chinese Han Population.

Recently, several studies have reported that the host immune response can be related to the RANKL/RANK/OPG signaling pathway. However, the associations of , and gene polymorphisms in the RANKL/RANK/OPG pathway with hepatitis C virus (HCV) infection outcomes remain unclear. In this case-control study, 768 persistent HCV infection and 503 spontaneous HCV clearance cases, and 1,259 control subjects were included. The Taman-MGB probe method was utilized to detect rs9525641, rs8686340, and rs2073618 genotypes. The distribution of three single nucleotide polymorphisms (SNPs) genotypes was analyzed using stata14.0. SNPs rs9525641, rs8086340, and rs2073618 genotype frequencies followed the Hardy-Weinberg natural population equilibrium ( = 0.637, 0.250, and 0.113, respectively). Also, rs9525641 was significantly associated with HCV chronicity risk in recessive (OR = 1.203, 95% CI: 1.018-1.420, = 0.030) and additive models (OR = 1.545, 95% CI: 1.150-2.075, = 0.004). The stratified analysis showed that rs9525641 variant genotypes were associated with HCV chronicity among people older than 50 years (OR =1.562, 95% CI: 1.079-2.262, = 0.018), females (OR = 1.667, 95% CI: 1.145-2.429, = 0.008), ALT <40 U/L (OR = 1.532, 95% CI: 1.074-2.286, = 0.018), and AST < 40 U/L (OR = 1.552, 95% CI: 1.095-2.201, = 0.014). rs9525641 was significantly associated with HCV chronicity in the Chinese population.