AI Article Synopsis
- Developmental programming involves a series of molecular decisions that mark the genome and create stable cell types in an organism.
- Key biological processes rely on the stable selection of one allele in each cell, including genomic imprinting, immune receptor selection, and X-chromosome inactivation in females.
- The authors suggest that asynchronous replication timing (ASRT) could be a critical mechanism for regulating and maintaining these genetic choices.
Article Abstract
Developmental programming is carried out by a sequence of molecular choices that epigenetically mark the genome to generate the stable cell types which make up the total organism. A number of important processes, such as genomic imprinting, selection of immune or olfactory receptors, and X-chromosome inactivation in females are dependent on the ability to stably choose one single allele in each cell. In this perspective, we propose that asynchronous replication timing (ASRT) serves as the basis for a sophisticated universal mechanism for mediating and maintaining these decisions.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8517340 | PMC |
| http://dx.doi.org/10.3389/fcell.2021.737681 | DOI Listing |
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