Aim: To investigate the therapeutic effect of Elemene combined with Nedaplatin (ECN) on malignant pleural effusion (MPE) and its adverse reactions.
Method: A retrospective study was conducted, three hundred and fifty-two patients with MPE were divided into two groups according to different treatment methods. One hundred and eighty-nine patients were given intrathoracic injection of ECN and classified in ECN group; one hundred and sixty-three cases in the Nedaplatin group were given intrathoracic injection of nedaplatin. Routine treatments were used to prevent adverse reactions.
Result: The effective rate of the ECN group was 57.05%, and that of the Nedaplatin group was 23.08%. The comparison results of adverse reactions between the two groups showed that there was no significant difference in leukopenia, thrombopenia, anemia, vomitting and diarrhea, fever, hepatic damage and renal damage. The level of thoracalgia in the ECN group was higher than that in the Nedaplatin group. There was no significant change in the number of CD8+ T cells between the two groups after treatment. The number of CD4+T cells in the ECN group increased after treatment was higher than the Nedaplatin group after treatment.
Conclusion: ECN treatment can improve clinical control of MPE with no serious adverse reaction, can effectively reduce the immunosuppressive effect of nedaplatin and enhance the immune function of MPE patients which is worthy of clinical application.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bulcan.2021.06.014 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Simple carbenes as hydrogen bond acceptors: determination of nucleophilicities and reduced nucleophilicities.
Phys Chem Chem Phys
December 2024
School of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS, UK.
Nucleophilicities for a range of simple carbene molecules acting as hydrogen bond acceptors B in forming complexes B⋯HX are reported. The carbenes chosen to fulfil the roles of a Lewis base are B = RM, -(CH)M, HCCM and two N-heterocyclic carbenes, where M is one of the group 14 tetrel atoms, C, Si, Ge or Sn and R = H, CH, and F. All the carbenes but CH have a singlet electronic ground state.
View Article and Find Full Text PDFAberrant Dynamic Network Connectivity Changes in Comorbid Depression and Overweight/Obesity: Insights From the Triple Network Model.
J Neurosci Res
December 2024
Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao, China.
The interaction between major depressive disorder (MDD) and overweight/obesity has received considerable attention owing to its widespread occurrence and the intricate biopsychological implications involved. Despite extensive research, the neural mechanisms underlying these comorbid conditions, particularly in terms of functional network connectivity (FNC), are still not well understood. This study aimed to clarify these mechanisms by utilizing resting-state functional magnetic resonance imaging (rs-fMRI) to examine both static and dynamic FNC.
View Article and Find Full Text PDFBioorthogonal Engineering of Bacterial Outer Membrane Vesicles for NIR-II Fluorescence Imaging-Guided Synergistic Enhanced Immunotherapy.
Anal Chem
December 2024
Department of Hepatopancreatobiliary Surgery, the First Affiliated Hospital & Center for Molecular Imaging Probe & Hunan Engineering Research Center for Early Diagnosis and Treatment of Liver Cancer, Cancer Research Institute, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China.
Article Synopsis
- Immunotherapy for triple-negative breast cancer (TNBC) faces challenges due to low immune system activation and a suppressive environment; however, bacterial outer membrane vesicles (OMVs) show promise as innovative agents.
- A two-step bacterial metabolic labeling technique was employed to create DPG-functionalized OMVs, which were enhanced with new indocyanine green (IR820) for better targeting and immune activation.
- The resulting OMV-DPG-IR820 stimulated strong immune responses and effectively inhibited tumor growth and metastasis, demonstrating a novel approach to improving immunotherapy for TNBC.
Postbiotic Effect of Escherichia coli CEC15 and Escherichia coli Nissle 1917 on a Murine Model of 5-FU-induced Intestinal Mucositis.
Probiotics Antimicrob Proteins
November 2024
Institute of Biological Sciences, Department of Genetics, Ecology, and Evolution, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Probiotics are live microorganisms that, when administered in adequate amounts, can bring health benefits to the host. Most of these organisms are found naturally in the human gastrointestinal tract. Escherichia coli strains Nissle 1917 (EcN), and CEC15 have shown beneficial effects in murine models of intestinal inflammation, such as colitis and mucositis.
View Article and Find Full Text PDFResting-state functional connectivity in gelotophobes: A neuroscientific perspective on the fear of laughter.
Behav Brain Res
February 2025
Department of Educational Psychology and Counseling, National Taiwan Normal University, Taiwan. Electronic address:
Gelotophobia, the fear of being laughed at, is characterized by heightened sensitivity to ridicule and a tendency to perceive laughter in social situations as mocking. Resting-state functional magnetic resonance imaging (rs-fMRI) acquires brain functional connectivity while the individual remains at rest, without engaging in specific tasks. Recent studies have investigated task-based fMRI and white matter in gelotophobes; however, the resting-state functional connectivity (rsFC) in this group remains unclear.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!