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Current Strategies and Future Dimensions in the Development of KRAS Inhibitors for Targeted Anticancer Therapy.
Drug Dev Res
February 2025
South University School of Pharmacy, Savannah, Giorgia, USA.
KRAS is a proto-oncogene that is found to be mutated in 15% of all metastatic cancers with high prevalence in pancreatic, lung, and colorectal cancers. Additionally, patients harboring KRAS mutations respond poorly to standard cancer therapy. As a result, KRAS is seen as an attractive target for targeted anticancer therapy.
View Article and Find Full Text PDFEconomic Viability of the Production of Peruvian Grunt () in RAS on the Peruvian-Chilean Desert Coast.
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December 2024
Escuela de Ingeniería Pesquera, Universidad Nacional Jorge Basadre Grohmann, Tacna 23004, Peru.
The Peruvian grunt is one of the most appreciated fish in Peruvian national markets. However, its reduced and irregular fishery is a paradigm of illegal, unreported, and unregulated fishing (IUU) in the Peruvian-Chilean coastal region. An important technological advancement has been achieved in the last decade in capture, management, nutrition, and broodstock maintenance to boost pilot experiences on the aquaculture of this species.
View Article and Find Full Text PDFLosartan May Prevent Clinically Significant Postoperative Fibrosis, But Large Database Studies May Not Provide an Answer.
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January 2025
Bone & Joint Sports Medicine Institute, Department of Orthopaedic Surgery, Naval Medical Center Portsmouth, Portsmouth, VA, USA; Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD. Electronic address:
Losartan and other modulators of the Renin-Angiotensin System (RAS) have been used for their anti-fibrotic effects by non-surgeons for decades where suppression of maladaptive scar deposition is helpful, such as heart failure and chronic kidney disease. Only recently have orthopaedic surgeons begun to explore whether these medications might reduce or prevent post-operative joint stiffness. The relationship between orthopaedic surgeons and fibrosis is a more complicated.
View Article and Find Full Text PDFp53: The Multifaceted Roles of Covalent Modifications in Cancer.
Pharmaceuticals (Basel)
December 2024
Institute of Biomedical Chemistry, Moscow 119121, Russia.
The p53 protein has attracted huge research interest over several decades due to its role as one of the most important tumor suppressors in mammals, which orchestrates a synchronous response from normal cells in the body to various forms of stress. The diverse cellular activities of the p53 protein are regulated mainly via its post-translational modifications (PTMs). PTMs affect p53 on several levels: at the level of the assembly of tetrameric complexes on DNA to transactivate its target genes, at the level of the assembly of tetrameric complexes on DNA to transactivate its target genes; at the level of proteolysis in the absence of stress; and on the contrary, at the level of augmented protein stability in response to stress signals.
View Article and Find Full Text PDFA Critical Review on microRNAs as Prognostic Biomarkers in Laryngeal Carcinoma.
Int J Mol Sci
December 2024
Department of ENT, Medical University, 1000 Sofia, Bulgaria.
During the past decade, a vast number of studies were dedicated to unravelling the obscurities of non-coding RNAs in all fields of the medical sciences. A great amount of data has been accumulated, and consequently a natural need for organization and classification in all subfields arises. The aim of this review is to summarize all reports on microRNAs that were delineated as prognostic biomarkers in laryngeal carcinoma.
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