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Percutaneous valve implantation or surgical replacement with mechanical or biological valves are standard therapies for severe valvular heart diseases. Prosthetic valve thrombosis, though rare, is a serious complication, particularly with mechanical prostheses. This study aimed to investigate the predictive value of platelet volume parameters, including mean platelet volume (MPV), platelet distribution width (PDW), and platelet-large cell ratio (P-LCR), for valvular thrombosis risk in patients undergoing valve replacement therapy.

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Statement Of Problem: Although immediate implant loading has shown promising clinical results and high survival rates, an increased risk of implant failure and complications has been reported. Achieving consistently predictable outcomes with this approach remains a challenge, but evidence-based guidelines to assist in selecting suitable patients are lacking.

Purpose: The purpose of this retrospective clinical study was to investigate the success rate, survival rate, and complications of immediate implant loading compared with early and delayed loading.

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Development of a prediction model for tube feeding dependence in HPV-associated oropharyngeal cancer patients undergoing chemoradiotherapy.

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December 2024

Radiation Medicine Program, Princess Margaret Cancer Centre, M5G 2M9, Toronto, Ontario, Canada; Department of Radiation Oncology, Princess Margaret Cancer Centre, University of Toronto, M5G 2M9 Toronto, Ontario. Electronic address:

Objectives: This study aimed to develop a prediction model for feeding tube dependence in a large homogenous cohort of HPV-associated oropharyngeal squamous cell carcinoma (HPV + OPSCC) patients receiving chemoradiotherapy (CRT). We further aimed to externally validate three previously published feeding tube prediction models on this cohort.

Materials And Methods: p16-confirmed HPV + OPSCC patients treated with definitive CRT at a tertiary cancer centre between April 2017 and February 2022 were identified.

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Background: Numerous factors can affect mobility of individuals with lower limb amputation, including prosthesis-dependent, physical and psychological determinants.Objective:This study aimed to investigate the prosthesis and health-related factors of mobility in people with nontraumatic unilateral transtibial amputation.Study Design:Cross-sectional observational study.

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Background: Total hip arthroplasty is one of the most successful and cost-effective interventions for improving quality of life. Dislocation is a well-recognised complication with a significant health and economic burden. The aim of this study was to establish the current management practices for patients presenting with a prosthetic hip dislocation.

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