AI Article Synopsis
- MDMA, commonly known as "ecstasy," has been shown through research to have the potential for abuse and can cause significant neurological damage in both short and long-term usage.
- Animal studies reveal that MDMA can lead to neurotoxic effects, suggesting serious risks to health, especially for its recreational users.
- This review summarizes recent preclinical and clinical findings regarding the central effects of MDMA and explores the mechanisms that contribute to the drug's neurotoxicity.
Article Abstract
Preclinical and clinical studies indicate that 3,4-methylenedioxymethamphetamine (MDMA; 'ecstasy'), in addition to having abuse potential, may elicit acute and persistent abnormalities of varying severity at the central level. Importantly, neurotoxic effects of MDMA have been demonstrated in experimental animals. Accordingly, central toxicity induced by MDMA may pose a serious harm for health, since MDMA is among the substances that are used for recreational purposes by young and adult people. This review provides a concise overview of recent findings from preclinical and clinical studies that evaluated the central effects of MDMA, and the mechanisms involved in the neurotoxicity induced by this amphetamine-related drug.
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| http://dx.doi.org/10.1016/j.expneurol.2021.113894 | DOI Listing |
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