AI Article Synopsis
- The study compares the immune microenvironment and autophagic activity between craniopharyngiomas and ameloblastomas due to their histologic and molecular similarities.
- 26 craniopharyngiomas and 14 ameloblastomas were analyzed for various immune markers, revealing that craniopharyngiomas had higher levels of autophagic protein LC3B and more CD8+ T cells and CD163+ macrophages compared to ameloblastomas.
- This research is the first to identify autophagic markers in craniopharyngiomas and to describe the immune environment in ameloblastomas, linking certain markers to overall patient survival.
Article Abstract
Background: Craniopharyngiomas and ameloblastomas show remarkable histologic and molecular similarities. The immune microenvironment of craniopharyngiomas has been recently studied showing interesting findings, while its composition in ameloblastomas is unknown. Similarly, some evidence of autophagic activity, a process of cellular constituents' degradation has been found in ameloblastomas, but no studies exist in craniopharyngiomas. Thus, the aim of the study is to compare factors of the immune microenvironment and the autophagic apparatus between these two tumor types.
Methods: 26 craniopharyngiomas and 14 ameloblastomas were immunohistochemically studied for PD-L1, CD8, CD20, S100, CD163, MECA-79, LC3B and p62.
Results: Craniopharyngiomas showed higher LC3B tumor cell expression, higher CD8+ T cells and higher CD163+ macrophages in comparison to ameloblastomas. LC3B tumor cell expression was associated with overall survival in craniopharyngioma patients and p62 nuclear expression was associated with overall survival in ameloblastoma patients.
Conclusion: This is the first study showing the presence of autophagic markers in craniopharyngiomas and describing the immune microenvironment of ameloblastomas.
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| http://dx.doi.org/10.1016/j.yexmp.2021.104712 | DOI Listing |
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