AI Article Synopsis
- The study investigates biomarkers to predict malignancy in patients with remitting seronegative symmetrical synovitis with pitting edema (RSPE), a rare inflammatory arthritis associated with higher cancer risk.
- A review of 51 RSPE patients found that 16.7% were diagnosed with malignancy, primarily hematological tumors, and identified elevated serum levels of basic fibroblast growth factor (bFGF) as a significant marker for malignancy.
- Results suggest that bFGF levels above 10 ng/mL may serve as a useful biomarker for predicting malignancy in RSPE patients.
Article Abstract
Objectives: Remitting seronegative symmetrical synovitis with pitting edema (RSPE) is a rare inflammatory arthritis, with a higher incidence of malignancy. The aim of this study is to identify biomarkers for predicting malignancy in RSPE.
Methods: A total of 51 patients with RSPE from September 2007 to May 2019 were retrospectively reviewed and followed for up to 5 years, with 15 patients with osteoarthritis (OA) and 14 patients with elderly-onset rheumatoid arthritis (EORA) as disease controls. Serum levels of angiogenesis cytokines were measured by electrochemiluminescent immunoassay and Luminex Human Magnetic Assay. Clinical data and laboratory parameters were analyzed to identify risk factors for malignancy.
Results: A total of forty-eight RSPE patients (94.1%) were available with follow-up data; 8 patients (16.7%) were diagnosed with malignancy, of which 6 patients were hematological tumor; and 2 patients were solid tumors. Serum levels of basic fibroblast growth factor (bFGF) were exclusively higher in RSPE patients with malignancy [14.21 (7.52, 23.18) ng/mL] than RSPE patients without malignancy [4.32 (2.88, 7.42) ng/mL], OA [3.20 (2.20, 5.30) ng/mL], and EORA [3.20 (2.20, 5.30) ng/mL]. The optimal cut-off value of bFGF for malignancy was 10ng/mL in RSPE. Logistic regression analysis indicated that elevation of bFGF was a risk factor for malignancy in RSPE.
Conclusions: This study indicated that bFGF was elevated in RSPE patients with malignancy and could serve as a biomarker for predicting paraneoplastic RSPE.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8518293 | PMC |
| http://dx.doi.org/10.1186/s13075-021-02638-0 | DOI Listing |
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