AI Article Synopsis
- The text discusses two patients diagnosed with meningoencephalomyelitis, which did not show involvement of other areas outside the central nervous system (CNS).
- MRI scans revealed specific patterns of enhancement in the brain and significant lesions in the spinal cord, with brain biopsies showing T-cell lymphoid infiltrates without Epstein-Barr virus presence.
- The initial diagnosis was isolated CNS-lymphomatoid granulomatosis, but detection of GFAP-immunoglobulin G in cerebrospinal fluid indicated a possible autoimmune condition, suggesting a connection between the two diagnoses.
Article Abstract
We report two patients with meningoencephalomyelitis without evidence of extra central nervous system (CNS) involvement. Brain MRI showed linear perivascular radial gadolinium enhancement patterns and spinal cord MRI showed longitudinal extensive T2-hyperintensity lesions. Pathological findings from brain biopsies were angiocentric T-cell predominant lymphoid infiltrates that lacked Epstein-Barr virus-positive atypical B cells. The patients were initially suspected to have isolated CNS-lymphomatoid granulomatosis (LYG). Thereafter, glial fibrillary acidic protein (GFAP)-immunoglobulin G were detected in their cerebrospinal fluid. This finding suggested autoimmune GFAP astrocytopathy. We speculate there is a link between isolated CNS-LYG and autoimmune GFAP astrocytopathy.
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| http://dx.doi.org/10.1016/j.jneuroim.2021.577748 | DOI Listing |
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