AI Article Synopsis
- The study investigates the link between kidney stones and the risk of opioid misuse, using data from inpatient and emergency departments across 4 states from 2005 to 2015.
- The analysis found that patients with multiple kidney stone episodes are at a significantly higher risk of developing opioid-related disorders (ORD), particularly among those treated in emergency settings or in Iowa.
- Factors such as younger age, chronic pain diagnosis, and fewer financial resources were associated with increased risk, while higher income and non-white race appeared to lower that risk.
Article Abstract
Objective: To evaluate the association between kidney stones and risk of subsequent opioid misuse.
Methods: The Healthcare Cost and Utilization Project's (HCUP) inpatient, ambulatory, and emergency department databases from 4 states were queried to identify associations with a primary diagnosis code related to kidney stones followed by a diagnosis of opioid abuse, dependence, or overdose between 2005, and 2015. Logistic regression was performed to determine the strength and significance of the relationship between number of primary kidney stone episodes and subsequent diagnosis of opioid misuse.
Results: The final cohort included 783,929 patients across 4 states. On multivariable analysis the number of primary stone encounters (PSE) was strongly associated with the risk of developing an opioid-related disorder (ORD) when adjusting for relevant covariates (odds ratio 1.3). Patients seen in the emergency department (OR 1.4) and those treated in Iowa (OR 2.9) were at higher risk for ORD than those seen in different contexts or states. Younger age increased the strength of this association. Higher income (OR 0.7) and non-white race (OR 0.7) reduced the risk of ORD, while a diagnosis of chronic pain (OR 3.5) increased risk.
Conclusion: Risk of subsequent diagnosis of ORD is increased in patients who have multiple episodes of care related to kidney stones.
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| http://dx.doi.org/10.1016/j.urology.2021.09.023 | DOI Listing |
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