A Microsatellite in the Coding Sequence of HLA-A/B Is a Mutation Hotspot in Colon Cancer With Microsatellite Instability.

Gastroenterology

Department of Pathology and Cell Biology, Herbert Irving Comprehensive Cancer Center (HICCC), Columbia Stem Cell Initiative (CSCI), Division of Digestive and Liver Diseases, Department of Medicine, Digestive and Liver Disease Research Center (DLDRC), Columbia University Medical Center, New York, New York.

Published: March 2022

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8881331PMC
http://dx.doi.org/10.1053/j.gastro.2021.10.006DOI Listing

Publication Analysis

Top Keywords

microsatellite coding
4
coding sequence
4
sequence hla-a/b
4
hla-a/b mutation
4
mutation hotspot
4
hotspot colon
4
colon cancer
4
cancer microsatellite
4
microsatellite instability
4
microsatellite
2

Similar Publications

SURFINs protein family expressed on surface of both infected red blood cell and merozoite surface making them as interesting vaccine candidate for erythrocytic stage of malaria infection. In this study, we analyze genetic variation of Pfsurf4.1 gene, copy number variation, and frequency of SURFIN4.

View Article and Find Full Text PDF

Genome-Wide Microsatellites in : Development, Distribution, Characterization, and Polymorphism.

Animals (Basel)

December 2024

Guangdong Provincial Key Laboratory of Fishery Ecology and Environment, South China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Guangzhou 510300, China.

The yellowfin seabream () is an economically important commercial mariculture fish in China and Southeast Asia. Only a few simple sequence repeats (SSRs) of have been isolated and reported, which has hindered breeding progress. A total of 318,862 SSRs were isolated and characterized from the genome in this study.

View Article and Find Full Text PDF

Genomic microsatellite characterization and development of polymorphic microsatellites in Eospalax baileyi.

Sci Rep

January 2025

Key Laboratory of Grassland Ecosystem (Ministry of Education), Pratacultural College, Gansu Agricultural University, Lanzhou, 730070, China.

Microsatellite markers are cost-effective, rapid, efficient, and show great advantages in in large-sample kinship analysis and population structure studies. However, microsatellite loci are seriously underdeveloped in non-model organisms. The plateau zokor (Eospalax baileyi) is a key species living underground in the Tibetan Plateau, the effective management of which has long been challenging.

View Article and Find Full Text PDF

Genetic relationship analysis and core collection construction of Eucalyptus grandis from Dongmen improved variety base: the largest eucalypt germplasm resource in China.

BMC Plant Biol

December 2024

State Key Laboratory of Tree Genetics and Breeding, National Engineering Research Center of Tree Breeding and Ecological Restoration, Key Laboratory of Genetics and Breeding in Forest Trees and Ornamental Plants of Ministry of Education, College of Biological Sciences and Technology, Beijing Forestry University, Beijing, 100083, China.

Background: Eucalyptus grandis, which was first comprehensively and systematically introduced to China in the 1980s, is one of the most important fast-growing tree species in the forestry industry. However, to date, no core collection has been selected from the germplasm resources of E. grandis based on growth and genetic relationship analysis.

View Article and Find Full Text PDF

is one of the two genera in the large fern family Aspleniaceae. A previous study explored the molecular phylogeny of this genus using several chloroplast DNA fragments and identified three major clades, one of which is the monophyletic Old World clade with southwestern China as its diversity center. To date, there were only a few studies conducted on chloroplast genomes in or Aspleniaceae, limiting the understanding of the plastome features and its role in evolution of this group.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!