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Life course socioeconomic position and care dependency in later life: a longitudinal multicohort study from 17 countries.
EClinicalMedicine
January 2025
Center for Smart and Healthy Buildings, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China.
Background: Care dependency, inability to perform basic daily tasks without assistance due to functional impairment, increases substantially with accelerated population ageing and becomes a pressing public health concern worldwide. Socioeconomic disadvantage has been shown to be associated with elevated risks of care dependency, but how risks are modified by changes in socioeconomic position remains unclear. From a life course perspective, we investigated the association between socioeconomic mobility across the lifespan and care dependency in later life.
View Article and Find Full Text PDFGenome-wide association study of anterior uveitis.
Br J Ophthalmol
December 2024
Department of Ophthalmology and Medical Research Center, Oulu University Hospital; Research Unit of Clinical Medicine, University of Oulu, Oulu, Finland.
Background/aims: The purpose of this study is to define genetic factors associated with anterior uveitis through genome-wide association study (GWAS).
Methods: In this GWAS meta-analysis, we combined data from the FinnGen, Estonian Biobank and UK Biobank with a total of 12 205 anterior uveitis cases and 917 145 controls. We performed a phenome-wide association study (PheWAS) to investigate associations across phenotypes and traits.
Toward Long-Life High-Voltage Aqueous Li-Ion Batteries: from Solvation Chemistry to Solid-Electrolyte-Interphase Layer Optimization Against Electron Tunneling Effect.
Adv Mater
December 2024
Department of Chemistry, Pohang University of Science and Technology (POSTECH), 37673, Pohang, Republic of Korea.
Water is pursued as an electrolyte solvent for its non-flammable nature compared to traditional organic solvents, yet its narrow electrochemical stability window (ESW) limits its performance. Solvation chemistry design is widely adopted as the key to suppress the reactivity of water, thereby expanding the ESW. In this study, an acetamide-based ternary eutectic electrolyte achieved an ESW ranging from 1.
View Article and Find Full Text PDFLabel-Free SERS Analysis of Biological and Physical Information Heterogeneity of Nanoscale Extracellular Vesicle by Matching Specific Sizes of Enhanced Particles.
Small
December 2024
Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, Shaanxi, 710049, China.
The heterogeneity of extracellular vesicles (EVs) surface information represents different functions, which is neglected in previous studies. In this study, a label-free SERS analysis approach is demonstrated to study fundamental EV biological and physical information heterogeneity by matching specific sizes of nano-enhanced particles. This strategy reveals informative, comprehensive, and high-quality SERS spectra of the overall exosome surface, and effectively circumvents the key information loss caused by the spatial resistance of NPs binding to the 293 exosomes' concave structure.
View Article and Find Full Text PDFIntroduction: Paediatric emergency department (ED) attendances and admissions in England are increasing. Fever is a common presenting problem for these attendances. Anxiety and misperceptions surrounding appropriate management of fever persist among parents.
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