cAAVe phaenomena: Beware of appearances!

Cell

Institute of Physiological Chemistry, University Medical Center Mainz, 55128 Mainz, Germany; Institute of Psychology, Psychiatry & Neuroscience, Centre for Developmental Neurobiology, King's College London, London SE1 1UL, UK; MRC Centre for Neurodevelopmental Disorders, King's College London, London SE1 1UL, UK; The Francis Crick Institute, London NW1 1AT, UK. Electronic address:

Published: October 2021

In this issue of Cell, Wang et al. come to the unsettling conclusion that adeno-associated viruses, despite being engineered for glia-specific expression, can become widely active in endogenous neurons, misleading researchers in their quest for efficient conversion of glia into neurons for brain repair.

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Source
http://dx.doi.org/10.1016/j.cell.2021.09.027DOI Listing

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