Unitary learning is a backpropagation (BP) method that serves to update unitary weights in fully connected deep complex-valued neural networks, meeting a prior unitary in an active modulation diffractive deep neural network. However, the square matrix characteristic of unitary weights in each layer results in its learning belonging to a small-sample training, which produces an almost useless network that has a fairly poor generalization capability. To alleviate such a serious over-fitting problem, in this Letter, optical random phase dropout is formulated and designed. The equivalence between unitary forward and diffractive networks deduces a synthetic mask that is seamlessly compounded with a computational modulation and a random sampling comb called dropout. The dropout is filled with random phases in its zero positions that satisfy the Bernoulli distribution, which could slightly deflect parts of transmitted optical rays in each output end to generate statistical inference networks. The enhancement of generalization benefits from the fact that massively parallel full connection with different optical links is involved in the training. The random phase comb introduced into unitary BP is in the form of conjugation, which indicates the significance of optical BP.
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http://dx.doi.org/10.1364/OL.428761 | DOI Listing |
Pharmacol Res
January 2025
Department of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Key Laboratory of Anesthesiology (Shanghai Jiao Tong University), Ministry of Education, Shanghai, China. Electronic address:
Biased µ-opioid receptor (MOR) agonists enhance pain relief by selectively activating G protein-coupled receptor signaling and minimizing β-arrestin-2 activation, resulting in fewer side effects. This multicenter Phase II/III trial evaluated the optimal dosage, efficacy, and safety of SHR8554, a biased MOR agonist, for postoperative pain management following orthopedic surgery. In Phase II, 121 patients were divided into four groups to receive varying patient-controlled analgesia (PCA) doses of SHR8554 or morphine.
View Article and Find Full Text PDFESMO Open
January 2025
Dana-Farber Cancer Institute, Boston, USA; Harvard School of Public Health, Boston, USA.
Background: Cancer researchers frequently consider the use of single-arm and randomized controlled clinical trial designs that leverage external data. The literature has reported extensively on how the use of external data can introduce bias through a variety of distortion mechanisms. In this article, we focus on a distortion mechanism that is often overlooked: informative censoring.
View Article and Find Full Text PDFESMO Open
January 2025
Clinical Trial Unit, Istituto Nazionale Tumori-IRCCS-Fondazione G. Pascale, Naples, Italy. Electronic address:
Background: The Hormonal Bone Effects (HOBOE) study tested whether adjuvant triptorelin plus either letrozole (L) or zoledronic acid (Z) plus L (ZL) was more effective than tamoxifen (T) in premenopausal patients with hormone receptor-positive (HR+) early breast cancer (BC). Here we report the long-term follow-up analysis.
Patients And Methods: HOBOE (ClinicalTrials.
Cancer Commun (Lond)
January 2025
Department of Breast Surgery, Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Centre, Shanghai, P. R. China.
Background: Hormone receptor-positive (HR+)/humaal growth factor receptor 2-negative (HER2-) breast cancer, the most common breast cancer type, has variable prognosis and high recurrence risk. Neoadjuvant therapy is recommended for median-high risk HR+/HER2- patients. This phase II, single-arm, prospective study aimed to explore appropriate neoadjuvant treatment strategies for HR+/HER2- breast cancer patients.
View Article and Find Full Text PDFJ Sports Sci
January 2025
Applied Sport, Technology, Exercise and Medicine Research Centre, Swansea University, Wales, UK.
We investigated the effects of low and high frequency isometric handgrip exercise training (IHGT) on resting blood pressure, and the affective/perceptual responses during training. Sixty young normotensive adults were randomised to either a no-intervention control group (CON: = 20; 12 female) or a group performing either two (LOW: = 20; 18 female) or four (HIGH: = 20; 13 female) sessions/week of IHGT for 4 weeks. IHGT involved 4 × 2-min holds at 30% maximal voluntary contraction using the dominant hand.
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