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Exposure to School Racial Segregation and Late-Life Cognitive Outcomes.
JAMA Netw Open
January 2025
Department of Health Policy and Management, Yale School of Public Health, New Haven, Connecticut.
Importance: Disparities in cognition, including dementia occurrence, persist between non-Hispanic Black (hereinafter, Black) and non-Hispanic White (hereinafter, White) older adults, and are possibly influenced by early educational differences stemming from structural racism. However, the association between school racial segregation and later-life cognition remains underexplored.
Objective: To investigate the association between childhood contextual exposure to school racial segregation and cognitive outcomes in later life.
Basic Science and Pathogenesis.
Alzheimers Dement
December 2024
The Jackson Laboratory, Bar Harbor, ME, USA.
Background: Late-onset Alzheimer's disease (LOAD) is the leading cause of dementia and a major contributor to increased mortality. Recent human datasets have revealed many LOAD genetic risk factors that are correlated with the degree of AD burden. Further, the complexity and heterogeneity of LOAD appears to be promoted by interactions between genetics and environmental factors such as diet, sedentary behavior, and exposure to toxicants, like lead (Pb), cadmium (Cd), and arsenic (As).
View Article and Find Full Text PDFClinical Manifestations.
Alzheimers Dement
December 2024
NYU Grossman School of Medicine, New York, NY, USA.
Background: We examined racial differences between measures of limbic white matter tracts and objective sleep parameters in cognitively unimpaired older-adults.
Method: This cross-sectional study included 170 community-dwelling cognitively unimpaired older-adults (mean±SD: age = 67.2±5.
Clinical Manifestations.
Alzheimers Dement
December 2024
UC Davis Alzheimer's Disease Center, Walnut Creek, CA, USA.
Background: Cognitive-test scores in the bottom 7% of a normative distribution (z-score < -1.50) are an essential component of the diagnosis of Mild Cognitive Impairment (MCI). However, different patients show MCI-compatible performance when evaluated using scoring models that account for the influences of different demographic variables (e.
View Article and Find Full Text PDFClinical Manifestations.
Alzheimers Dement
December 2024
University of California, Davis, Davis, CA, USA.
Background: Depressive symptoms are associated with reduced brain integrity. However, it is unclear if this association holds among a racially and ethnically diverse population aged ≥90 years and if there are differences by gender.
Method: The LifeAfter90 Study enrolled 212 long-term members of Kaiser Permanente Northern California who were ≥90 years old, without dementia diagnosis, and received neuroimaging via 3T MRI.
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