Few-shot learning aims to recognize novel classes from a few examples. Although significant progress has been made in the image domain, few-shot video classification is relatively unexplored. We argue that previous methods underestimate the importance of video feature learning and propose to learn spatiotemporal features using a 3D CNN. Proposing a two-stage approach that learns video features on base classes followed by fine-tuning the classifiers on novel classes, we show that this simple baseline approach outperforms prior few-shot video classification methods by over 20 points on existing benchmarks. To circumvent the need of labeled examples, we present two novel approaches that yield further improvement. First, we leverage tag-labeled videos from a large dataset using tag retrieval followed by selecting the best clips with visual similarities. Second, we learn generative adversarial networks that generate video features of novel classes from their semantic embeddings. Moreover, we find existing benchmarks are limited because they only focus on 5 novel classes in each testing episode and introduce more realistic benchmarks by involving more novel classes, i.e., few-shot learning, as well as a mixture of novel and base classes, i.e., generalized few-shot learning. The experimental results show that our retrieval and feature generation approach significantly outperform the baseline approach on the new benchmarks.
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http://dx.doi.org/10.1109/TPAMI.2021.3120550 | DOI Listing |
Curr Opin Psychiatry
December 2024
Departments of Psychiatry &, Behavioral Sciences and Pediatrics, University of Kansas Medical Centre, Kansas City, Kansas, United States.
Purpose Of Review: Prader-Willi (PWS) and Angelman (AS) syndromes arise from errors in 15q11-q13 imprinting. This review describes recent advances in genomics and how these expand our understanding of these rare disorders, guiding treatment strategies to improve patient outcomes.
Recent Findings: PWS features include severe infantile hypotonia, failure to thrive, hypogonadism, developmental delay, behavioral and psychiatric features, hyperphagia, and morbid obesity, if unmanaged.
Dalton Trans
January 2025
Institute of Biopharmaceutical Research, Liaocheng University, Liaocheng 252059, P. R. China.
Pt(IV) complexes as prodrugs of Pt(II) drugs exhibit numerous advantages such as enhanced stability, reduced toxicity, increased oral bioavailability, and efficacy in overcoming the drug resistance of Pt(II) compounds, which underscore their significant potential in the advancement of novel Pt anticancer agents. Furthermore, protective autophagy is pivotal in sustaining tumor cell homeostasis and modulating the tumor microenvironment (TME), thereby representing a critical target for the development of antitumor drugs. Specific inhibition or activation of autophagy during chemotherapy would break the internal homeostasis in the TME and increase antitumor activities.
View Article and Find Full Text PDFAllergy
January 2025
Schroeder Allergy and Immunology Research Institute, Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Canada.
Allergic reactions to foods are primarily driven by allergen-binding immunoglobulin (Ig)E antibodies. IgE-expressing cells can be generated through direct switching from IgM to IgE or a sequential class switching pathway where activated B cells first switch to an intermediary isotype, most frequently IgG1, and then to IgE. It has been proposed that sequential class switch recombination is involved in augmenting the severity of allergic reactions, generating high affinity IgE, differentiation of IgE plasma cells, and in holding the memory of IgE responses.
View Article and Find Full Text PDFChem Rec
January 2025
Department of Pharmacy, Banasthali Vidyapith, Rajasthan, India.
Seven-membered nitrogen-containing heterocycles, particularly azepine-based compounds, represent an intriguing class of molecules with vast arrays of applications. These compounds have garnered considerable attention in synthetic and medicinal chemistry due to their non-planar, non-aromatic features, which offer structural flexibility and diversity to design new drugs with improved pharmacological properties. This review summarizes the recent advances in the synthesis of azepine derivatives, including eco-friendly methodologies that align with the principles of green chemistry, which emphasize atom economy, sustainability, and waste reduction.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
January 2025
Kunming Institute of Botany Chinese Academy of Sciences, State Key Laboratory of Phytochemistry and Plant Resources in West China, Lanhei Road 132, Heilongtan, 650201, Kunming, CHINA.
Plant sesterterpenoids are an extremely rare family of natural products that generally possess novel chemical structures and diverse biological activities. Here, we report the discovery of an unprecedented group of minor plant sesterterpenoids, gracilisoids B-E (2-5), which feature two types of highly functionalized bicyclo[3.2.
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