The studies on IgG-3 subclass in the course of acute lymphoblastic leukemia (ALL) in children were performed. The presence of this IgG subclass was not shown, using chromatography on AGP-Sepharose for its isolation and Protein A-Sepharose for its identification. The possibilities of excretion of this IgG subclass with urine and proteolytic digestion in neutral pH by serum enzymes were excluded. Acid alpha-1-glycoprotein (AGP) isolated from serum of children with ALL interacts with IgG-3 of normal serum.
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