AI Article Synopsis
- A 78-year-old woman with rheumatoid arthritis developed a severe fungal eye infection (including conjunctivitis and scleritis) due to Scedosporium apiospermum after becoming neutropenic from her medication.
- The infection was diagnosed through mycological culture and advanced analysis techniques, leading to initial treatment with surgery and antifungal drugs like voriconazole.
- Despite a positive response to treatment, a relapse occurred, necessitating an extended antifungal therapy for 12 months to fully eradicate the infection, which is rare in immunosuppressed patients.
Article Abstract
We report a case of invasive fungal infection with necrotizing conjunctivitis, scleritis and unilateral panuveitis caused by Scedosporium apiospermum in a 78-year-old woman that developed neutropenia by drugs indicated for rheumatoid arthritis. The etiological diagnosis was confirmed by mycological culture of an ocular secretion with the support of MALDI-TOF-TOF analysis and histopathological findings. The treatment involved surgical debridements together with topical solution and systemic therapy with voriconazole and steroids with a favorable evolution after 2 months of treatment. A relapse required a second therapeutic course for an additional 12 months with improvement and eradication of the agent. Fungal conjunctivitis due to S. apiospermum is a rare event associated with immunosuppressed patients. Its treatment involves surgical debridements and prolonged antifungal therapy.
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| http://dx.doi.org/10.4067/S0716-10182021000400568 | DOI Listing |
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