Background: The upper respiratory tract (URT) is the primary entry site for severe acute respiratory syndrome 2 (SARS-CoV-2) and other respiratory viruses, but its involvement in viral amplification and pathogenesis remains incompletely understood.
Methods: In this study, we investigated primary nasal epithelial cultures, as well as vital explanted tissues, to scrutinize the tropism of wild-type SARS-CoV-2 and the recently emerged B.1.1.7 variant.
Results: Our analyses revealed a widespread replication competence of SARS-CoV-2 in polarized nasal epithelium as well as in the examined URT and salivary gland tissues, which was also shared by the B.1.1.7 virus.
Conclusions: In our analyses, we highlighted the active role of these anatomic sites in coronavirus disease 2019.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8524635 | PMC |
| http://dx.doi.org/10.1093/infdis/jiab523 | DOI Listing |
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