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Increased Risk of Retinal Vasculitis in Patients With Systemic Lupus Erythematosus: A Nationwide Population-Based Cohort Study. | LitMetric

AI Article Synopsis

  • The study aimed to explore the connection between systemic lupus erythematosus (SLE) and the likelihood of developing retinal vasculitis (RV) using a large database from Taiwan.
  • Researchers compared 11,586 SLE patients with 231,720 non-SLE individuals, matched by age and sex, and found that SLE patients had a much higher incidence rate of RV (56.39 vs. 2.45 cases per 100,000 person-years).
  • After adjustments for various factors, SLE patients were found to be 22.99 times more likely to develop RV, with the research concluding that SLE significantly increases the risk of this eye condition compared to those without SLE.

Article Abstract

To evaluate the relationship between systemic lupus erythematosus (SLE) and the risk of retinal vasculitis (RV) using a population-based database. Using the 1997-2013 Taiwanese National Health Insurance Database, we identified newly diagnosed SLE patients between 2001 and 2012 as the SLE group. We matched the SLE group with non-SLE individuals selected from a representative one million sample of the population in a 1:20 ratio for age, sex, and the year of the index date. After adjusting for potential confounders, including urbanization of the patient's residence, the level of the payroll-related insured amount, and selected comorbidities, we examined the association between SLE and the risk of RV using the Cox proportional hazard model shown as hazard ratios (HRs) with 95% confidence intervals (CIs). Sensitivity analyses were conducted using various definitions of RV. We included 11,586 patients with SLE and 231,720 matched non-SLE individuals. The mean age of the study participants was 36.7 ± 16.9 years, and the female-to-male ratio was 6.8:1. The incidence rates of RV were 56.39 cases per 100,000 person-years and 2.45 cases per 100,000 person-years, respectively. After adjusting for potential confounders, the incidence rate of RV in the SLE cohort was 22.99 times higher than that in the non-SLE cohort (56.39 vs. 2.45 per 100,000 person-years). The adjusted HR for RV in the SLE group was 23.61 (95% CI, 14.94-37.32). The results remained robust in the sensitivity analysis. This nationwide population-based study revealed that SLE patients had a significantly higher risk of RV than non-SLE individuals.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8505770PMC
http://dx.doi.org/10.3389/fmed.2021.739883DOI Listing

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