AI Article Synopsis
- - Sirtuins are a group of seven proteins (SIRT1-7) in humans that utilize NAD to modify protein lysine residues, influencing various biological processes like cell growth, metabolism, and movement.
- - These proteins play distinct roles and are involved in the regulation of various diseases, such as cancer, neurodegeneration, and metabolic disorders, making them crucial for our understanding of human health.
- - The review discusses how genetic and drug-based approaches can influence sirtuins, highlighting the growing interest in developing treatments that target these proteins to address their role in diseases.
Article Abstract
Sirtuins use NAD to remove various acyl groups from protein lysine residues. Through working on different substrate proteins, they display many biological functions, including regulation of cell proliferation, genome stability, metabolism, and cell migration. There are seven sirtuins in humans, SIRT1-7, each with unique enzymatic activities, regulatory mechanisms, subcellular localizations, and substrate scopes. They have been indicated in many human diseases, including cancer, neurodegeneration, microbial infection, metabolic and autoimmune diseases. Consequently, interests in development of sirtuin modulators have increased in the past decade. In this brief review, we specifically summarize genetic and pharmacological modulations of sirtuins in cancer, neurological, and cardiovascular diseases. We further anticipate this review will be helpful for scrutinizing the significance of sirtuins in the studied diseases.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8505532 | PMC |
| http://dx.doi.org/10.3389/fphar.2021.735044 | DOI Listing |
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