AI Article Synopsis
- Emerging SARS-CoV-2 variants are concerning due to their increased ability to infect different hosts, cause illness, and evade vaccine-induced immunity.
- Vaccinated subjects with the DNA vaccine INO-4800 showed neutralizing antibodies against all variants, although responses were lower for the B.1.351 variant.
- T cell responses (specifically IFNγ) remained strong across all variants, indicating robust cellular immunity.
Article Abstract
Global surveillance has identified emerging SARS-CoV-2 variants of concern (VOC) associated with broadened host specificity, pathogenicity, and immune evasion to vaccine-induced immunity. Here we compared humoral and cellular responses against SARS-CoV-2 VOC in subjects immunized with the DNA vaccine, INO-4800. INO-4800 vaccination induced neutralizing antibodies against all variants tested, with reduced levels detected against B.1.351. IFNγ T cell responses were fully maintained against all variants tested.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8516974 | PMC |
| http://dx.doi.org/10.1038/s41541-021-00384-7 | DOI Listing |
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