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A Qualitative Study of School Nurses' Experience of Secondary Trauma.
Creat Nurs
August 2024
Seton Hall University, South Orange, New Jersey.
This qualitative descriptive study explored school nurses' experiences of exposure to reports of trauma from those in their care. Online interviews of school nurses practicing in NJ, USA, were recorded and transcribed verbatim. The study found that school nurses were exposed to reports of others' trauma to varying degrees, with those serving in urban settings reporting more stories of exposure than those in suburban settings.
View Article and Find Full Text PDF' transforming the self through vocational rehabilitation for people with acquired brain injury.
Scand J Occup Ther
December 2024
Centre for Rehabilitation and Health, University College Absalon, Denmark.
Background: Acquired Brain injury (ABI) causes ripples throughout the occupational and social fabric. It enters people's lives at a significant personal cost, encroaching on people's sense of self. Vocational rehabilitation is a viable venue to regain control of their life and support them in forming a new sense of self.
View Article and Find Full Text PDFThe ripple effect of trauma: Evaluating vulnerability, post-traumatic stress symptoms, and aggression within a child and adolescent population.
Child Abuse Negl
August 2024
Department of Curriculum and Instruction, Jacksonville State University, 700 Pelham Road North, Jacksonville, AL 36265, USA. Electronic address:
Background: The deleterious effects of experiencing adverse childhood experiences (ACEs), especially those associated with child abuse and neglect (CM-ACEs), is well documented. Two common behavioral and emotional concerns observed in children following CM-ACEs is post-traumatic stress and aggression. While support for cognitive models explaining both of these outcomes exists, little is known about any shared cognitive vulnerabilities that may explain the presence of both.
View Article and Find Full Text PDFMiR-23b-3p Improves Brain Damage after Status Epilepticus by Reducing the Formation of Pathological High-Frequency Oscillations via Inhibition of cx43 in Rat Hippocampus.
ACS Chem Neurosci
July 2024
Department of Neurology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing 400014, China.
Article Synopsis
- The study aimed to assess the safety and effectiveness of miR-23b-3p in reducing seizures and its regulatory interaction with Cx43 in a rat model of seizures induced by lithium chloride-pilocarpine.
- Results showed that both valproate sodium (VPA) and miR-23b-3p overexpression significantly delayed the onset of severe seizures and reduced the frequency of spontaneous recurrent seizures compared to control groups.
- After 28 days, VPA and miR-23b-3p treated rats exhibited lower rates of hippocampal cell necrosis and higher synapse counts in the CA1 region, suggesting that miR-23b-3p may mitigate seizure effects by targeting Cx
β-catenin mRNA encapsulated in SM-102 lipid nanoparticles enhances bone formation in a murine tibia fracture repair model.
Bioact Mater
September 2024
Colorado State University, School of Biomedical Engineering, Fort Collins CO, USA.
Fractures continue to be a global economic burden as there are currently no osteoanabolic drugs approved to accelerate fracture healing. In this study, we aimed to develop an osteoanabolic therapy which activates the Wnt/β-catenin pathway, a molecular driver of endochondral ossification. We hypothesize that using an mRNA-based therapeutic encoding β-catenin could promote cartilage to bone transformation formation by activating the canonical Wnt signaling pathway in chondrocytes.
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