AI Article Synopsis
- - Colon cancer is a prevalent type of malignant tumor in the digestive system, and while oxaliplatin is used for treatment, it often yields poor results.
- - Researchers tested an IDO inhibitor called D-MT in combination with oxaliplatin on mice with colon cancer, examining aspects like immune cell activity and tumor growth.
- - The results indicated that this combination therapy not only reduced tumor growth and boosted survival rates in mice but also increased the presence of vital immune cells, suggesting a promising new approach for treating colon cancer, particularly in patients who may not respond well to oxaliplatin alone.
Article Abstract
Colon cancer is one of the most common malignant tumors in the digestive system. Although oxaliplatin, a chemotherapy drug, has been clinically used to treat colon cancer, its therapeutic effect is unsatisfactory. It has been proved that indoleamine dioxygenase 2,3 (IDO) is a tumor immunosuppressive factor for the immune response. Herein, an IDO inhibitor, D-MT (indoximod, 1-Methyl-D-tryptophan), was combined with oxaliplatin to treat colon cancer in mice. T cell infiltration in tumor tissues, the ratios of immune cells in the spleens, and the tumor growth and survival of the mice were detected and recorded. The results showed that the combination of oxaliplatin and D-MT significantly inhibited tumor growth and prolonged the survival of tumor-bearing mice. More importantly, the combination treatment increased the ratios of CD4 T, CD8 T and NK cells from the spleen in tumor-bearing mice, and prompted T cell infiltration in tumor tissues. This study provided a new therapeutic strategy for colon cancer treatment in the clinic, especially for patients with oxaliplatin resistance.
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| http://dx.doi.org/10.1016/j.intimp.2021.108203 | DOI Listing |
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