AI Article Synopsis
- LINC00662 is a long noncoding RNA located on chromosome 19q11, known to be upregulated in at least 14 different tumors and associated with poor cancer prognosis and treatment resistance.
- LINC00662 functions as a competing endogenous RNA (ceRNA) for at least 8 microRNAs, influencing multiple signaling pathways including ERK, Wnt/β-catenin, Hippo, and SMD.
- Additionally, LINC00662 promotes stem-like characteristics in lung cancer cells and enhances the activity of oncogenes by reducing the methylation of specific genes linked to hepatocellular carcinoma.
Article Abstract
LINC00662 is located on chromosome 19q11 and is 2085 bp long. It is a long noncoding RNA (lncRNA) newly discovered. LINC00662 expression is upregulated in at least 14 tumors. In addition, the upregulation of LINC00662 expression is also closely related to the poor prognosis of cancer patients and resistance to radiotherapy and chemotherapy. LINC00662 can act as a ceRNA of at least 8 miRNAs. By regulating these miRNAs and their downstream genes, LINC00662 participates in the regulation of four signaling pathways, including the extracellular signal-regulated kinase (ERK) signaling pathway, the Wnt/β-catenin signaling pathway, the Hippo signaling pathway, and the SMD signaling pathway. In addition, the abnormal upregulation of LINC00662 can promote the stem-like features of lung cancer cells. LINC00662 can reduce the promoter methylation level of s-adenosylmethionine (SAM)-dependent hepatocellular carcinoma (HCC)-promoting genes by regulating the MAT1A/SAM and AHCY/SAH axes, thereby promoting the activation of oncogenes. This article summarizes the molecular regulation mechanism of LINC00662 in cancer and the diagnostic and prognostic value of LINC00662 in cancer.
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| http://dx.doi.org/10.1002/jcp.30599 | DOI Listing |
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