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The Crossroads of Glycoscience, Infection, and Immunology. | LitMetric

AI Article Synopsis

  • Advances in glycoscience are enhancing research opportunities in immunology and microbiology, particularly regarding how microbes interact with the host's immune system.
  • Glycan structures are crucial in these interactions, impacting host-pathogen relationships by serving as receptors and influencing immune responses.
  • A 2020 workshop highlighted the potential of new glycoscience tools to deepen our understanding of glycans' roles in immune responses and to aid in developing better diagnostics and treatments for infections and immune disorders.

Article Abstract

Advances in experimental capabilities in the glycosciences offer expanding opportunities for discovery in the broad areas of immunology and microbiology. These two disciplines overlap when microbial infection stimulates host immune responses and glycan structures are central in the processes that occur during all such encounters. Microbial glycans mediate host-pathogen interactions by acting as surface receptors or ligands, functioning as virulence factors, impeding host immune responses, or playing other roles in the struggle between host and microbe. In the context of the host, glycosylation drives cell-cell interactions that initiate and regulate the host response and modulates the effects of antibodies and soluble immune mediators. This perspective reports on a workshop organized jointly by the National Institute of Allergy and Infectious Diseases and the National Institute of Dental and Craniofacial Research in May 2020. The conference addressed the use of emerging glycoscience tools and resources to advance investigation of glycans and their roles in microbe-host interactions, immune-mediated diseases, and immune cell recognition and function. Future discoveries in these areas will increase fundamental scientific understanding and have the potential to improve diagnosis and treatment of infections and immune dysregulation.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504252PMC
http://dx.doi.org/10.3389/fmicb.2021.731008DOI Listing

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