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Clinical Remission of Cutaneous Lymphoma in a Dog Treated with Verdinexor.
J Am Anim Hosp Assoc
September 2024
From Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts (J.L.G., S.A., G.M.-R.); and.
A 5 yr old female spayed pit bull terrier mix was evaluated for development of multiple dermal nodules over the previous 2 wk with concurrent weight loss and lethargy. A definitive diagnosis of cutaneous epitheliotropic T-cell lymphoma was obtained through histopathology and immunohistochemistry. Treatment was initiated with 32.
View Article and Find Full Text PDFEfficacy of verdinexor for the treatment of naïve canine epitheliotropic cutaneous T-cell lymphoma: An open-label pilot study.
Vet Dermatol
October 2024
Animal Dermatology Group Inc, Tustin, California, USA.
Background: Verdinexor (Laverdia-CA1; Dechra Veterinary Products), a selective inhibitor of nuclear export, has been utilised for treatment of non-Hodgkin T-cell lymphoma in dogs. However, the efficacy of verdinexor has not been evaluated for cutaneous epitheliotropic T-cell lymphoma (CETL).
Hypothesis/objectives: To evaluate the efficacy of verdinexor for the treatment of CETL.
Primary third eyelid lymphoma with aggressive local behavior in a dog.
Top Companion Anim Med
March 2024
Setor de Patologia Veterinária, Departamento de Patologia Clínica Veterinária, Faculdade de Veterinária (FAVET), Universidade Federal do Rio Grande do Sul (UFRGS), Av. Bento Gonçalves, 9090, Pr. 42505, Porto Alegre, Brazil; Programa de Pós-Graduação em Ciências Veterinárias, Faculdade de Veterinária (FAVET), Universidade Federal do Rio Grande do Sul (UFRGS), Av. Bento Gonçalves, 9090, Porto Alegre, Brazil.
Lymphoma is the most common hematopoietic neoplasm in dogs. However, cases primarily involving the third eyelid are rarely reported in the species. The subtype most frequently described in this location is marginal zone lymphoma of the mucosa-associated lymphoid tissue, which has an indolent behavior.
View Article and Find Full Text PDFSpindle cell cutaneous epitheliotropic T-cell lymphoma in an American Bulldog.
J Comp Pathol
April 2024
Department of Veterinary Pathobiology, Veterinary Medical Diagnostic Laboratory, College of Veterinary Medicine, University of Missouri, 901 E. Campus Loop, Columbia, Missouri 65211, USA. Electronic address:
An 8-year-old American Bulldog developed coalescing exophytic bulbous nodules that grew rapidly on the left pinna and a single cutaneous mass on the left flank. Histological examination of the pinnal biopsy by a diagnostic laboratory revealed a densely cellular neoplasm with haphazardly arranged round to spindle cells with high mitotic activity and epitheliotropism. The initial diagnosis was a poorly differentiated malignant neoplasm with differential diagnoses including melanoma, tumour of histiocytic origin and, less likely, a pleomorphic lymphoma.
View Article and Find Full Text PDFDiascopy and histopathological evaluation of nonblanching erythematous dermatoses in dogs.
Vet Dermatol
June 2024
Centre for Clinical Veterinary Medicine, University of Munich, Munich, Germany.
Background: Diascopy is a point-of-care diagnostic test used to differentiate skin erythema due to vascular dilation from haemorrhage. In the veterinary literature, only a handful of diseases have been described to be associated with a negative (nonblanching) diascopy result, and histological investigation of haemorrhage has been inconsistent.
Objectives: Retrospective study to undertake a histopathological investigation of canine, nonblanching erythematous dermatoses for the presence or absence of haemorrhage and vascular changes.
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