Objective: This prospective case series aims to evaluate the clinical impact of a hypochlorous acid oxidising solution (AOS) in association with usual standard of care (SoC) on wound bed preparation (WBP) in patients with hard-to-heal ulcers of various aetiologies. The AOS (Nexodyn, APR Applied Pharma Research S.A., Switzerland) comprises three main features: highly pure and stabilised hypochlorous acid, acidic pH and high reduction-oxidation potential.
Method: Between February 2015 and February 2017, patients who met the inclusion criteria were treated with AOS and usual SoC. Data collection ran for 70 days: T0-T70. A baseline assessment was undertaken at T0; parameters assessed at fortnightly visits included: WBP score, area and depth of ulcer, duration, pain, Bates-Jensen score and infection status.
Results: A total of 60 patients took part in the study. By T70, 68.3% of wounds had healed or improved and a significant wound size reduction of 21% was observed (p<0.001), despite a mean wound duration of 20.6 months. All wounds were free of local infection and cellulitis; 10% were colonised. WBP scores improved, while Bates-Jensen and pain scores fell significantly over time.
Conclusion: This evaluation suggests that AOS might represent a valuable therapeutic addition for an optimal WBP in the routine management of hard-to-heal ulcers of different aetiologies.
Declaration Of Interest: ER worked as a consultant for APR Applied Pharma Research S.A. The authors have no other conflicts of interest.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.12968/jowc.2021.30.10.830 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A Mitochondria-Targeted Iridium(iii) Phosphorescent Probe for Selective Detection of Hypochlorite in Living Cells.
Chem Asian J
December 2024
Nanjing University of Posts and Telecommunications, 9 Wenyuan road, nanjing, CHINA.
Hypochlorous acid(HClO)/hypochlorite ion (ClO-) is a highly reactive oxygen species (ROS) that play a crucial role in various biological processes. In this paper, a "turn-on" phosphorescent probe (Ir-TPP) for detecting ClO- in mitochondria was designed and synthesized. In solution, Ir-TPP is minimal emission due to rapid isomerization of C=N-OH as an efficient non-radiative decay process.
View Article and Find Full Text PDFAnalysis of pulp histological response to pulpotomy performed with white mineral trioxide aggregate mixed with 2.25% sodium hypochlorite gel in humans: a randomized controlled clinical trial.
Sci Rep
December 2024
Department of Pediatric Dentistry, Faculty of Dentistry, Damascus University, Damascus, Syrian Arab Republic.
This study aimed to evaluate the histological success of pulpotomy in primary molars using white mineral trioxide aggregate (WMTA) mixed with 2.25% sodium hypochlorite (NaOCl) gel and to evaluate in vitro its physical and chemical properties. The study had a clinical stage and an in-vitro stage.
View Article and Find Full Text PDFSmear layer removal comparing conventional irrigation, passive ultrasonic irrigation, EndoActivator System, and a new sonic device (Perfect Clean System) by scanning electron microscopy: An ex vivo study.
PLoS One
December 2024
Department of Endodontics, School of Health and Biosciences, Pontifical Catholic University of Paraná -PUC/PR, Curitiba, Paraná, Brazil.
Aim: This study evaluated the smear layer removal provided by conventional, sonic, and ultrasonic irrigation techniques.
Methodology: Forty extracted human mandibular first premolars were selected and instrumented using the ProTaper Next System files and 2.5% sodium hypochlorite.
Rational Development of a Lipid Droplets and Hypochlorous Acid In-Sequence Responsive Fluorescent Probe for Accurate Imaging of Atherosclerotic Plaques.
Anal Chem
December 2024
Shandong Provincial Key Laboratory of Detection Technology for Tumor Markers, College of Chemistry and Chemical Engineering, Linyi University, Linyi 276000, China.
To answer the call for effective and timely intervention in cardiovascular diseases (CVDs), the development of fluorescent probes that can precisely identify atherosclerotic plaques, the root cause of various fatal CVDs, is highly desirable but remains a great challenge. Herein, by integrating bis(trifluoromethyl)benzyl and phenothiazine into the coumarin matrix, a robust fluorescent probe, NOR1, has been developed. NOR1 responds sequentially to lipid droplets (LDs) and HClO via fluorescence turn-on and ratiometric readouts, respectively, with a fast response rate (within 70 s for LDs and 80 s for HClO), excellent sensitivity (detection limit: 0.
View Article and Find Full Text PDFA sequence-activatable dual-locked fluorescent probe for simultaneous detection of hypochlorous acid and peroxynitrite during drug-induced liver injury.
Talanta
December 2024
School of Water Conservancy and Environment, University of Jinan, Jinan, 250022, China. Electronic address:
Drug-induced liver injury (DILI) is a crucial factor that poses a significant threat to human health. DILI process leads to the changes of reactive oxygen species and reactive nitrogen species content in cells, which leads to oxidative and nitrosative stress in cells. However, the high reactivity of hypochlorous acid (HOCl) and peroxynitrite (ONOO⁻), combined with a lack of in situ imaging techniques, has hindered a detailed understanding of their roles in DILI.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!