AI Article Synopsis
- Bacterial-viral interactions in saliva can impact health during respiratory viral infections like influenza and SARS-CoV, but their role during SARS-CoV-2 infection is still unclear.
- This study aimed to explore how saliva microbiota interacts with SARS-CoV-2 by comparing the microbiome of hospitalized COVID-19 patients to that of healthy controls using advanced genetic sequencing.
- While overall saliva microbiome diversity didn’t show major differences, significant changes in specific bacterial taxa were linked to the levels of SARS-CoV-2 viral load, suggesting possible implications for COVID-19 clinical outcomes.
Article Abstract
Bacterial-viral interactions in saliva have been associated with morbidity and mortality for respiratory viruses such as influenza and SARS-CoV. However, such transkingdom relationships during SARS-CoV-2 infection are currently unknown. Here, we aimed to elucidate the relationship between saliva microbiota and SARS-CoV-2 in a cohort of newly hospitalized COVID-19 patients and controls. We used 16S rRNA sequencing to compare microbiome diversity and taxonomic composition between COVID-19 patients ( = 53) and controls ( = 59) and based on saliva SARS-CoV-2 viral load as measured using reverse transcription PCR (RT-PCR). The saliva microbiome did not differ markedly between COVID-19 patients and controls. However, we identified significant differential abundance of numerous taxa based on saliva SARS-CoV-2 viral load, including multiple species within and . Alterations to the saliva microbiome based on SARS-CoV-2 viral load indicate potential biologically relevant bacterial-viral relationships which may affect clinical outcomes in COVID-19 disease.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8515944 | PMC |
| http://dx.doi.org/10.1128/Spectrum.00055-21 | DOI Listing |
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