Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1093/humupd/dmab032 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Biomarkers.
Alzheimers Dement
December 2024
Institute of Neurosciences. Department of Biomedicine, Faculty of Medicine, University of Barcelona, Barcelona, Spain.
Large neuroimaging datasets play a crucial role in longitudinal modelling and prediction of neurodegenerative diseases, as they provide the opportunity to study biomarker trajectories over time. Noteworthy, the availability of these large datasets coexists with a paradigm shift in the theoretical understanding of these diseases: while classical studies aimed at defining disease signatures as group patterns obtained with static cross-sectional analyses, novel approaches focus on providing individual predictions in the context of phenotypical and temporal heterogeneity. This scenario is often aggravated by the fact that datasets are not homogeneous and suffer from missing points and noisy data.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
Urmia University of Medical Science, Urmia, West Azarbayjan, Iran (Islamic Republic of).
Background: Cerebral microbleeds (CMBs) are small, round aggregations of hemosiderin-laden macrophages that indicate leakage of blood products from cerebral vessels damaged by β-amyloid-40 (Aβ), which is the basis of cerebral amyloid angiopathy (CAA). Pathology studies have demonstrated a high correlation between CAA and AD, both amyloid-related pathologies. CMBs can be visualized commonly using T2*-weighted MRI, as small foci of decreased signal intensity.
View Article and Find Full Text PDFPublic Health.
Alzheimers Dement
December 2024
PHARMO Institute for Drug Outcomes Research, Utrecht, Netherlands.
Background: General practitioners (GPs) play a crucial role in recognizing cognitive deficits and diagnosing dementia. Currently, dementia diagnosis in primary care is prone to be missed or delayed. Electronic health records from GPs can offer insights into the trajectory leading up to a dementia diagnosis.
View Article and Find Full Text PDFDeveloping Topics.
Alzheimers Dement
December 2024
Michigan Alzheimer's Disease Research Center - University of Michigan, Ann Arbor, MI, USA.
Background: Longitudinal studies of Alzheimer's and related dementias (ADRD) are crucial to understanding disease progression. Retention among study participants is vital to successful longitudinal research, as dropout can skew the subject population in ways that significantly compromise study outcomes (e.g.
View Article and Find Full Text PDFDeveloping Topics.
Alzheimers Dement
December 2024
Massachusetts General Hospital, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Background: Recent breakthroughs in the treatment of Alzheimer's Disease underscore the critical needs for early detection. In clinical settings, the diagnosis of Alzheimer's disease and related dementias (ADRD) is often delayed or overlooked, potentially missing critical opportunities for timely care and treatment. Cognitive symptoms can appear many years before the stage of dementia, potentially serving as a trigger for thorough cognitive assessments, which could prompt an early diagnosis of cognitive decline.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!