Performing the Roux-en-Y gastric bypass (RYGBP) in obese Yucatan minipigs provides an opportunity to explore the mechanisms behind the effects of this surgery in controlled environmental and nutritional conditions. We hypothesized that RYGBP in these minipigs would induce changes at multiple levels, as in obese humans. We sought to characterize RYGBP in a diet-induced obese minipig model, compared with a pair-fed sham group. After inducing obesity with an ad libitum high-fat/high-sugar diet, we performed RYGBP (n = 7) or sham surgery (n = 6). Oral glucose tolerance tests (OGTT) were performed before and after surgery. Histological analyses were conducted to compare the alimentary limb at sacrifice with tissue sampled during RYGBP surgery. One death occurred in the RYGBP group at postoperative day (POD) 3. Before sacrifice, weight loss was the same across groups. GLP-1 secretion (OGTT) was significantly higher at 15, 30 and 60 min at POD 7, and at 30 and 60 min at POD 30 in the RYGBP group. Incremental insulin area under the curve increased significantly after RYGBP (p = 0.02). RYGBP induced extensive remodeling of the alimentary limb. Results show that RYGBP can be safely performed in obese minipigs, and changes mimic those observed in humans.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8511153 | PMC |
| http://dx.doi.org/10.1038/s41598-021-98575-8 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Intussusception Within a Jejunostomy With Closed Loop Obstruction: A Case Report.
Cureus
August 2024
Collage of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, SAU.
Jejunojejunal intussusception is a rare yet severe complication of Roux-en-Y gastric bypass (RYGBP) surgery. We are presenting a unique case of retrograde jejunal intussusception with a closed-loop blockage and an associated abdominal herniation that occurred two years after a laparoscopic RYGBP. The patient presented with abdominal pain, nausea, and vomiting, prompting a clinical diagnosis and a biphasic contrast-enhanced computed tomography (CT) scan, which later revealed a complicated jejunal intussusception with signs of ischemia showing decreased wall enhancement and distal collapsed jejunal walls with complete closed-loop bowel obstruction.
View Article and Find Full Text PDFOpen-bore MRI Scanner Assessment of Epicardial Adipose Tissue after Bariatric Surgery: A Pilot Study.
Endocr Metab Immune Disord Drug Targets
August 2024
National Institute of Obesity Cure (INCO)-Bariatric Unit, IRCCS, Policlinico San Donato, Piazza Edmondo Malan, 2, 20097, San Donato Milanese, Milan, Italy.
Background: The recognition of epicardial adipose tissue (EAT) as a cardiac risk factor has increased the interest in strategies that target cardiac adipose tissue.
Aim: The effect of bariatric and metabolic surgery (BMS)-induced weight loss on EAT volume was evaluated in this study.
Methods: Fifteen bariatric patients, with (MS) or without (wMS) Metabolic Syndrome, underwent magnetic resonance imaging (MRI) using an open-bore scanner to assess EAT volume, visceral adipose tissue (VAT) thickness, and other cardiac morpho-functional parameters at baseline and 12 months after BMS.
Gastric mucocele after conversion of open butterfly gastroplasty to Roux-En-Y gastric bypass - A case report with a review of the literature.
Int J Surg Case Rep
May 2024
General Surgery Department, King Abdualaziz Hospital, Mecca, Saudi Arabia.
Introduction: There has been a significant increase in the prevalence of morbid obesity across the globe. Various non-surgical weight loss options have shown limited long-term efficacy, leading to the popularity of surgical treatment alternatives with long-term efficacy.
Presentation Of Case: This case report describes the development of a gastric mucocele in a 51-year-old female patient.
Prospective evaluation of transoral outlet reduction (TORe) after Roux-en-Y gastric bypass (RYGB) failure.
Surg Endosc
March 2024
Digestive Surgery, Montpellier University Hospital, Montpellier, France.
Article Synopsis
- Weight regain after Roux-en-Y gastric bypass (RYGB) is often due to issues like the stretching of the gastro-jejunal connection. The transoral outlet reduction (TORe) procedure is a less invasive option to address this.
- A study involving 73 patients evaluated the effectiveness of the TORe procedure combined with standard nutrition/behavioral management versus standard management alone. Results showed participants who underwent TORe had significantly higher excess weight loss at 12 months (13.5% vs. -0.77%).
- While TORe showed promising weight loss results, it also had a notable rate of adverse events (20%), including severe complications like perforations, indicating it carries risks even though it's minimally invasive.
Endoscopic Revisional Gastroplasty After Bariatric Surgery with a Single-Channel Endoscope.
Obes Surg
February 2024
ELSAN, Clinique Bouchard, Marseille, France.
Background: Less invasive endoscopic bariatric procedures are under development for the management of recurrence of obesity. The purpose of the current manuscript was to evaluate the safety of the endoscopic revisional gastroplasty (ERG) for patients with recurrence of weight gain following different bariatric procedures.
Materials And Methods: This is a retrospective single-center study over 22 patients using the ERG between January 2020 to July 2022 at Bouchard Private Hospital (Marseille, France).
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!