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Effect of Rate-Adaptive Atrial Support Compared to VDD Pacing in Cardiac Resynchronization Therapy Recipients: A Randomized Cross-Over Study.
Am Heart J
December 2024
Department of Cardiology, San Maurizio Regional Hospital, Bolzano, Italy.
Background: Cardiac resynchronization therapy (CRT) is a cornerstone treatment for heart failure, yet the optimal pacing mode remains uncertain. This study investigates the impact of DDDR (rate-adaptive atrial support) versus VDD pacing modes on functional capacity and echocardiographic outcomes in patients with CRT-defibrillators.
Methods: In a multicenter, double-blind, crossover trial, 26 sinus rhythm patients undergoing CRT-defibrillator implantation were randomized to DDDR at 60 beats-per-minute or VDD at 30 beats-per-minute.
Late gadolinium enhancement and outcome of cardiac resynchronization therapy in non-ischemic cardiomyopathy.
Int J Cardiol
January 2025
Cardiology Department, Bellvitge University Hospital, Hospitalet de Llobregat, Barcelona, Spain; Bioheart Group, Cardiovascular, Respiratory and Systemic Diseases and cellular aging Program, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Spain. Electronic address:
Article Synopsis
- The study investigates whether cardiac resynchronization therapy with a defibrillator (CRTD) is better than therapy with a pacemaker (CRTP) for patients with non-ischemic cardiomyopathy (NICM) and low risk of arrhythmias.
- It analyzes data from 167 NICM patients, looking for predictors of heart function improvement (echocardiographic response) and serious heart rhythm issues (arrhythmias) over a median follow-up of 63 months.
- Findings reveal that patients without late gadolinium enhancement (LGE) show a much higher response rate to CRT (81% vs. 53%) and no arrhythmic events, suggesting they are ideal candidates for CRTP rather than
Cost-Effectiveness Ratio Analysis of LBBaP Versus BVP in Heart Failure Patients With LBBB.
Pacing Clin Electrophysiol
November 2024
Department of Cardiology, First Affiliated Hospital, Nanjing Medical University, Nanjing, China.
Background: For the initial treatment strategy for patients with cardiac resynchronization therapy (CRT) indications, whether to choose left bundle branch area pacing (LBBaP) or biventricular pacing (BVP) remains controversial. We aimed to investigate the cost-effectiveness ratio (CER) of LBBaP and BVP in heart failure (HF) patients with left bundle branch block (LBBB).
Methods: This observational study included HF patients with LBBB who underwent successful LBBaP or BVP.
Comparison of electrocardiogram parameters and echocardiographic response between distinct left bundle branch area pacing modes in heart failure patients.
Front Cardiovasc Med
August 2024
Department of Cardiology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Background: Left bundle branch area pacing (LBBAP) has become an alternative method for cardiac resynchronization therapy. Various modes of LBBAP have been determined, including left bundle trunk pacing (LBTP), left anterior branch pacing (LAFP) and left posterior branch pacing (LPFP). However, whether the outcomes of various pacing modes differ in heart failure (HF) patients is still unclear.
View Article and Find Full Text PDFEmergent role of dynamic optimization in cardiac resynchronization therapy: Systematic review and network meta-analysis.
ESC Heart Fail
December 2024
Centre for Translational Medicine, Semmelweis University, Budapest, Hungary.
Aims: Suboptimal device programming is frequent in non-responders to cardiac resynchronization therapy (CRT). However, the role of device optimization and the most appropriate technique are still unknown. The aim of our study was to analyse the effect of different CRT optimization techniques within a network meta-analysis.
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