A phytochemical investigation on the roots of medicinal plant resulted in the isolation of 10 new highly oxygenated C quassinoids longifolactones G‒P (-), along with four known ones (-). Their chemical structures and absolute configurations were unambiguously elucidated on the basis of comprehensive spectroscopic analysis and X-ray crystallographic data. Notably, compound is a rare pentacyclic C quassinoid featuring a densely functionalized 2,5-dioxatricyclo[5.2.2.0]undecane core. Compound represents the first example of quassinoids containing a 14,15-epoxy functionality, and features an unusual α-oriented hydroxyl group at C-14. All isolated compounds were evaluated for their anti-proliferation activities on human leukemia cells. Among the isolates, compounds , , , and potently inhibited the in vitro proliferation of K562 and HL-60 cells with IC values ranging from 2.90 to 8.20 μM.
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| http://dx.doi.org/10.3390/molecules26195939 | DOI Listing |
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