AI Article Synopsis
- Gui Zhen Cao is an herbal remedy in traditional Chinese medicine effective for treating diarrhea, dysentery, inflammation, and toxicity, with documented sources found in ethnomedicinal reports globally.!* -
- In vitro tests revealed that the herb plants contain high levels of beneficial phytochemicals, particularly tannins, saponins, and alkaloids, which exhibit significant anticandida activity, especially from the leaves' hexane extract.!* -
- Further purification techniques like HPLC-DAD and GC-MS/MS identified two potent anticandida compounds, dehydroabietic acid and linoleic acid, which showed impressive inhibition rates of 85% and 92%, respectively.!*
Article Abstract
Gui Zhen Cao is an herbal formulation that has been documented in Chinese traditional medicine as a remedy for diarrhea, dysentery, inflammation, and toxicity. The sources of this formulation ( L., (Lour.) Merr. & Sherff, L.) are also listed in ethnomedicinal reports all over the world. In this study, all these plants are tested for in vitro anticandida activity. A quantitative evaluation of the phytochemicals in all these plants indicated that their vegetative parts are rich in tannins, saponins, oxalates, cyanogenic glycoside and lipids; moreover, the roots have high percentages of alkaloids, flavonoids, and phenols. The results indicated significant anticandida activity, especially for the hexane extract of leaves which inhibited (42.54%), (46.98%), (50.89%), (40.56%), and (50.24%). The extract was subjected to silica gel chromatography and 220 fractions were obtained. Purification by High Performance Liquid Chromatography with Diode-Array Detection (HPLC-DAD) and Gas Chromatography tandem Mass Spectrometry (GC-MS/MS) analysis led to the identification of two anticandida compounds: dehydroabietic and linoleic acid having an inhibition of 85 and 92%, respectively.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8510080 | PMC |
| http://dx.doi.org/10.3390/molecules26195820 | DOI Listing |
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