AI Article Synopsis
- ACLFS is a serious condition that arises in patients with chronic liver disease, marked by high mortality rates, organ failures, and intense inflammation.
- The paper reviews various diagnostic criteria and clinical features associated with ACLF, spotlighting its recognition as a distinct syndrome.
- Treatment approaches include managing organ failures, addressing underlying causes, and evaluating liver transplantation options, while more research is essential for understanding the syndrome better and developing new treatments.
Article Abstract
Acute-on-chronic liver failure (ACLF) is a syndrome that develops in patients with acutely decompensated chronic liver disease. It is characterised by high 28-day mortality, the presence of one or more organ failures (OFs) and a variable but severe grade of systemic inflammation. Despite the peculiarity of each one, every definition proposed for ACLF recognizes it as a proper clinical entity. In this paper, we provide an overview of the diagnostic criteria proposed by the different scientific societies and the clinical characteristics of the syndrome. Established and experimental treatments are also described. Among the former, the most relevant are directed to support organ failures, treat precipitating factors and carry out early assessment for liver transplantation (LT). Further studies are needed to better clarify pathophysiology of the syndrome and discover new therapies.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509281 | PMC |
| http://dx.doi.org/10.3390/jcm10194406 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!