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Deuterium metabolic imaging in the human brain at 9.4 Tesla with high spatial and temporal resolution. | LitMetric
Purpose : To present first highly spatially resolved deuterium metabolic imaging (DMI) measurements of the human brain acquired with a dedicated coil design and a fast chemical shift imaging (CSI) sequence at an ultrahigh field strength of B = 9.4 T. H metabolic measurements with a temporal resolution of 10 min enabled the investigation of the glucose metabolism in healthy human subjects.Methods : The study was performed with a double-tuned coil with 10 TxRx channels for H and 8TxRx/2Rx channels for H and an Ernst angle 3D CSI sequence with a nominal spatial resolution of 2.97 ml and a temporal resolution of 10 min.Results : The metabolism of [6,6'-H]-labeled glucose due to the TCA cycle could be made visible in high resolution metabolite images of deuterated water, glucose and Glx over the entire human brain.Conclusion : X-nuclei MRSI as DMI can highly benefit from ultrahigh field strength enabling higher temporal and spatial resolutions.
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